Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORT1 | Q99523 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 5/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19253680 | 0.86 | ALDH1A1 (0.64) | SORT1GAAPOLBLMNAHPGD | |
| SCHEMBL30310013 | 0.77 | ALDH1A1 (0.65) | SORT1GAAPOLBLMNAHPGD | |
| SCHEMBL30310014 | 0.77 | ALDH1A1 (0.65) | SORT1GAAPOLBLMNAHPGD | |
| SCHEMBL28981214 | 0.77 | ALDH1A1 (0.65) | SORT1GAAPOLBLMNAHPGD | |
| SCHEMBL14082269 | 0.76 | TRPV1 (0.65) | SORT1GAAPOLBLMNASMN1; SMN2 | |
| SCHEMBL12501761 | 0.75 | MEN1 (0.77) | SORT1GAAPOLBLMNAHPGD | |
| SCHEMBL14920831 | 0.75 | SORT1 (0.65) | SORT1GAAPOLBLMNAHPGD | |
| SCHEMBL15903183 | 0.74 | SORT1 (1.00) | SORT1GAAPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL28110473 | 0.73 | ALDH1A1 (0.74) | SORT1GAALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL14082708 | 0.73 | SORT1 (0.59) | SORT1GAAPOLBLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10420753-B2 | Combination therapies for treatment of spinal muscular atrophy | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2019-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10420753-B2 | Combination therapies for treatment of spinal muscular atrophy | SMN1; SMN2, MUSK, MYOF | SORT1 3587/4885GAA 139/4885POLB 376/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.