Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORT1 | Q99523 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | EDNRA | P25101 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | GLS | O94925 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3922902 | 0.82 | L3MBTL1 (0.48) | SORT1MAPTKDM4EGAAKMT2A | |
| SCHEMBL28941022 | 0.74 | SORT1 (0.54) | SORT1MAPTKDM4EGAAEGLN2 | |
| SCHEMBL14009931 | 0.72 | GLS (0.50) | SORT1MAPTKDM4EGAAL3MBTL1 | |
| SCHEMBL18802301 | 0.70 | HPGD (0.53) | SORT1MAPTKDM4EGAAL3MBTL1 | |
| SCHEMBL18624726 | 0.68 | SORT1 (0.46) | SORT1MAPTKDM4EGAAMEN1 | |
| SCHEMBL31451576 | 0.68 | SORT1 (0.46) | SORT1MAPTKDM4EGAA | |
| SCHEMBL30071321 | 0.68 | SORT1 (0.46) | SORT1MAPTKDM4EGAAL3MBTL1 | |
| SCHEMBL2189033 | 0.67 | SORT1 (0.48) | SORT1MAPTKDM4EGAARAB9A | |
| SCHEMBL17816472 | 0.66 | NPC1 (0.41) | MEN1KMT2ARAB9A | |
| SCHEMBL12883364 | 0.64 | SORT1 (0.37) | SORT1MAPTKDM4EGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233839-B1 | HETEROCYCLYL LINKED IMIDAZOPYRIDAZINE DERIVATIVES AS PI3KBETA INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-09-25 | — | — | EP | disclosed |