Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.37 |
| ▸ | FLT3 | P36888 | 3/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21386473 | 0.80 | KDR (0.64) | KDRFLT3HDAC1HDAC6LCK | |
| SCHEMBL21668695 | 0.80 | KDR (0.64) | KDRFLT3HDAC1HDAC6LCK | |
| SCHEMBL21668629 | 0.79 | HDAC3 (0.38) | KDRFLT3HDAC3HDAC1HDAC4 | |
| SCHEMBL24486690 | 0.70 | KDR (0.56) | KDRFLT3HDAC1HDAC6LCK | |
| SCHEMBL24486699 | 0.70 | KDR (0.56) | KDRFLT3HDAC1HDAC6LCK | |
| SCHEMBL21386467 | 0.70 | KDR (0.61) | KDRFLT3HDAC1HDAC6LCK | |
| SCHEMBL21668601 | 0.70 | KDR (0.61) | KDRFLT3HDAC1HDAC6LCK | |
| SCHEMBL28428802 | 0.69 | KDR (0.72) | KDRFLT3HDAC1HDAC6LCK | |
| SCHEMBL29967987 | 0.68 | MEN1 (0.37) | KDRFLT3HDAC3HDAC1HDAC2 | |
| SCHEMBL14981887 | 0.59 | HDAC4 (0.71) | HDAC3HDAC1HDAC4HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3543228-B1 | COMPOUND HAVING ANTICANCER ACTIVITY, AND PREPARATION METHOD AND APPLICATION THEREOF | 3D MEDICINES BEIJING CO LTD (CN) | 2022-12-28 | — | — | EP | disclosed |
| EP-3543228-A1 | COMPOUND HAVING ANTICANCER ACTIVITY, AND PREPARATION METHOD AND APPLICATION THEREOF | 3D Medicines (Beijing) Co., Ltd. (CN) | 2019-09-25 | — | — | EP | disclosed |