SCHEMBL21386549

SCHEMBL21386549

CCc1c(C)ccc(CCc2ccc(C)cc2C2CC2)c1F

nearest known ligand 0.36

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 1/20 0.32
DRD4 P21917 1/20 0.32
DRD3 P35462 1/20 0.32
TAAR1 Q96RJ0 1/20 0.31
PTGDR2 Q9Y5Y4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18842728 0.85 TAAR1 (0.33) DRD2DRD4DRD3TAAR1PTGDR2
SCHEMBL22622686 0.83 DRD2 (0.33) DRD2DRD4DRD3TAAR1PTGDR2
SCHEMBL16962103 0.76 PTGDR2 (0.37) DRD2DRD4DRD3TAAR1PTGDR2
SCHEMBL16954238 0.76 MAPT (0.42) DRD2DRD4DRD3PTGDR2
SCHEMBL21387111 0.75
SCHEMBL24390809 0.74
SCHEMBL19682257 0.71 NOS3 (0.31)
SCHEMBL21386541 0.70 NOS3 (0.30)
SCHEMBL11933394 0.69 CTSL (0.32)
SCHEMBL16956272 0.68 DRD2 (0.47) DRD2DRD4DRD3PTGDR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3739020-B1 LIQUID-CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2023-08-23 EP disclosed
WO-2022090109-A1 AROMATIC ISOTHIOCYANATES MERCK PATENT GMBH (DE) 2022-05-05 WO disclosed
WO-2022090098-A1 AROMATIC ISOTHIOCYANATES MERCK PATENT GMBH (DE) 2022-05-05 WO disclosed
WO-2022090099-A1 AROMATIC ISOTHIOCYANATES MERCK PATENT GMBH (DE) 2022-05-05 WO disclosed
WO-2022008474-A1 OPTICAL COMPONENT MERCK PATENT GMBH (DE) 2022-01-13 WO disclosed
WO-2021069535-A1 FLUORINATED AROMATIC COMPOUNDS MERCK PATENT GMBH (DE) 2021-04-15 WO disclosed
EP-3739020-A1 LIQUID-CRYSTALLINE MEDIUM Merck Patent GmbH (DE) 2020-11-18 EP disclosed
EP-3733816-A1 ISOTHIOCYANATO-TOLANES Merck Patent GmbH (DE) 2020-11-04 EP disclosed
EP-3543313-B1 LIQUID-CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2020-10-07 EP disclosed
EP-3543314-B1 LIQUID-CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2020-09-09 EP disclosed
WO-2020120586-A1 LIQUID-CRYSTAL MEDIUM MERCK PATENT GMBH (DE) 2020-06-18 WO disclosed
EP-3543313-A1 LIQUID-CRYSTALLINE MEDIUM Merck Patent GmbH (DE) 2019-09-25 EP disclosed
EP-3543314-A1 LIQUID-CRYSTALLINE MEDIUM Merck Patent GmbH (DE) 2019-09-25 EP disclosed