Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 7/20 | 1.00 |
| ▸ | BCHE | P06276 | 6/20 | 0.67 |
| ▸ | FAAH | O00519 | 1/20 | 0.67 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.67 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.67 |
| ▸ | PDE5A | O76074 | 1/20 | 0.67 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.67 |
| ▸ | APP | P05067 | 1/20 | 0.67 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.67 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.67 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.67 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.67 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.67 |
| ▸ | DRD4 | P21917 | 1/20 | 0.67 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.67 |
| ▸ | MAOB | P27338 | 1/20 | 0.67 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4207017 | 0.99 | ACHE (0.98) | ACHEBCHEFAAHABCC4CACNA1F | |
| SCHEMBL14215561 | 0.89 | ACHE (0.80) | ACHEBCHEFAAHABCC4CACNA1F | |
| SCHEMBL4201579 | 0.89 | ACHE (0.80) | ACHEBCHEFAAHABCC4CACNA1F | |
| SCHEMBL4200443 | 0.89 | ACHE (0.80) | ACHEBCHEFAAHABCC4CACNA1F | |
| SCHEMBL4199845 | 0.89 | ACHE (0.80) | ACHEBCHEFAAHABCC4CACNA1F | |
| Hydrochloric Acid SCHEMBL4207095 | 0.88 | ACHE (0.79) | ACHEBCHEFAAHABCC4CACNA1F | |
| Hydrochloric Acid SCHEMBL4213294 | 0.88 | ACHE (0.79) | ACHEBCHEFAAHABCC4CACNA1F | |
| Hydrochloric Acid SCHEMBL4196260 | 0.88 | ACHE (0.79) | ACHEBCHEFAAHABCC4CACNA1F | |
| SCHEMBL4203792 | 0.88 | ACHE (0.78) | ACHEBCHEFAAHABCC4CACNA1F | |
| Hydrochloric Acid SCHEMBL4203039 | 0.87 | ACHE (0.77) | ACHEBCHEFAAHABCC4CACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 104 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110053981-A1 | Methods and Compositions Using Cholinesterase Inhibitors | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-03-03 | — | — | US | claimed |
| EP-2140868-A1 | Use of a cholinesterase inhibitor for the treatment of dementia and cognitive impairments associated with or caused by chemotherapy | Eisai R&D Management Co., Ltd. (JP) | 2010-01-06 | — | — | EP | claimed |
| EP-2138177-A1 | Use of a cholinesterase inhibitor for the treatment of dementia and cognitive impairments | Eisai R&D Management Co., Ltd. (JP) | 2009-12-30 | — | — | EP | claimed |
| EP-2133078-A1 | Use of a cholinesterase inhibitor for the treatment of dementia and cognitive impairments | Eisai R&D Management Co., Ltd. (JP) | 2009-12-16 | — | — | EP | claimed |
| EP-2130538-A1 | Use of a cholinesterase inhibitor for the delaying the onset of Alzheimer's disease | Eisai R&D Management Co., Ltd. (JP) | 2009-12-09 | — | — | EP | claimed |
| US-20090137629-A1 | Sigma receptor binding agent containing indanone derivative | IIMURA YOICHI | 2009-05-28 | — | — | US | claimed |
| US-20090042939-A1 | Methods and Compositions Using Cholinesterase Inhibitors | EISAI CO., LTD. (JP) | 2009-02-12 | — | — | US | claimed |
| US-20090042940-A1 | METHODS AND COMPOSITIONS USING CHOLINESTERASE INHIBITORS | EISAI CO., LTD. (JP) | 2009-02-12 | — | — | US | claimed |
| US-20080312189-A1 | Cadasil Treatment with Cholinesterase Inhibitors | EISAI CO., LTD. (JP) | 2008-12-18 | — | — | US | claimed |
| US-20080045500-A1 | Nerve Regeneration Stimulator | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2008-02-21 | — | — | US | claimed |
| US-20040122051-A1 | Methods for treating cognitive impairments or dementia | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2004-06-24 | — | — | US | claimed |
| WO-2004034963-A2 | METHODS AND COMPOSITIONS USING CHOLINESTERASE INHIBITORS | EISAI CO., LTD. (JP) | 2004-04-29 | — | — | WO | claimed |
| US-6689795-B2 | ADMINISTERING CHOLINESTERASE INHIBITOR SUCH AS 1-BENZYL-4-((5,6-DIMETHOXY-1-INDANON)-2-YL)METHYLPIPERIDINE HYDROCHLORIDE, WHICH IS ALSO KNOWN AS DONEPEZIL HYDROCHLORIDE FOR THERAPY OF DEMENTIA DUE TO HIV DISEASE | EISAI CO., LTD. (JP) | 2004-02-10 | — | — | US | claimed |
| WO-2003092606-A2 | CHOLINESTERASE INHIBITORS TO PREVENT INJURIES CAUSED BY CHEMICALS | EISAI CO., LTD. (JP) | 2003-11-13 | — | — | WO | claimed |
| JP-2003525903-A | — | — | 2003-09-02 | — | — | JP | claimed |
| EP-1311272-A1 | NOVEL METHODS USING CHOLINESTERASE INHIBITORS | Eisai Co., Ltd. (JP) | 2003-05-21 | — | — | EP | claimed |
| EP-1311272-A4 | NOVEL METHODS USING CHOLINESTERASE INHIBITORS | EISAI CO LTD (JP) | 2003-05-21 | — | — | EP | claimed |
| WO-2001066114-A1 | NOVEL METHODS USING CHOLINESTERASE INHIBITORS | EISAI CO., LTD. (JP) | 2001-09-13 | — | — | WO | claimed |
| EP-0673927-A1 | 4-[2-indanyl-1-one]alkylpiperidines as anticholinergic agents | Eisai Co., Ltd. (JP) | 1995-09-27 | — | — | EP | claimed |
| EP-0296560-A2 | 1,4-Substituted piperidines as acetylcholinesterase inhibitors and their use for the treatment of Alzheimer's disease | Eisai Co., Ltd. (JP) | 1988-12-28 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045500-A1 | Nerve Regeneration Stimulator | ACHE, NGF, GAP43 | ACHE 1/4885BCHE 5/4885FAAH 947/4885 |
| US-20040122051-A1 | Methods for treating cognitive impairments or dementia | CHRNA5, CHRNA4, FCER2 | ACHE 8/4885BCHE 50/4885FAAH 2510/4885 |
| US-20090042939-A1 | Methods and Compositions Using Cholinesterase Inhibitors | PSEN1, BACE1, PSENEN | ACHE 26/4885BCHE 137/4885FAAH 861/4885 |
| US-20090137629-A1 | Sigma receptor binding agent containing indanone derivative | SIGMAR1, TMEM97, OPRK1 | ACHE 608/4885BCHE 1667/4885FAAH 2437/4885 |
| US-20080312189-A1 | Cadasil Treatment with Cholinesterase Inhibitors | NOTCH3, NOTCH2, NOTCH4 | ACHE 156/4885BCHE 38/4885FAAH 1617/4885 |
| US-20110053981-A1 | Methods and Compositions Using Cholinesterase Inhibitors | PSEN1, BACE1, PSENEN | ACHE 26/4885BCHE 137/4885FAAH 861/4885 |
| US-20090042940-A1 | METHODS AND COMPOSITIONS USING CHOLINESTERASE INHIBITORS | PSEN1, BACE1, PSENEN | ACHE 26/4885BCHE 137/4885FAAH 861/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.