SCHEMBL21390811

SCHEMBL21390811

CC(O)(CC(=O)CCCc1nc2cc(F)c(C#N)cc2n1C1(C)CCC1)c1ccccc1F

nearest known ligand 0.32

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
AR P10275 5/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21390926 0.98 AR (0.31) AR
SCHEMBL21390797 0.89 PTGDR2 (0.31) AR
SCHEMBL21390799 0.89 PTGDR2 (0.31) AR
SCHEMBL21390895 0.88 GPR119 (0.31) AR
SCHEMBL21390802 0.86 CYP11B1 (0.30)
SCHEMBL21390930 0.85 HDAC3 (0.30)
SCHEMBL21354596 0.82 AR (0.35) AR
SCHEMBL30315476 0.82 AR (0.35) AR
SCHEMBL21391175 0.76 ACACB (0.33)
SCHEMBL21391043 0.76 ACSS2 (0.41)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019183148-A1 KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE KNOPP BIOSCIENCES LLC (US) 2019-09-26 WO disclosed