Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | APLNR | P35414 | 11/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TNF | P01375 | 2/20 | 0.33 |
| ▸ | LITAF | Q99732 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21390891 | 0.84 | TNF (0.36) | APLNRPDE10AJAK1TNFLITAF | |
| SCHEMBL21390679 | 0.81 | TNF (0.36) | APLNRPDE10AJAK1TNFLITAF | |
| SCHEMBL21391170 | 0.79 | KDM2B (0.33) | APLNR | |
| SCHEMBL23132031 | 0.79 | CYP11B2 (0.41) | — | |
| SCHEMBL21391130 | 0.78 | CYP11B2 (0.38) | PDE10A | |
| SCHEMBL21390682 | 0.77 | JAK1 (0.32) | JAK1TSHR | |
| SCHEMBL21390947 | 0.77 | — | — | |
| SCHEMBL21354604 | 0.77 | EGFR (0.40) | HTR3AALDH1A1TSHR | |
| SCHEMBL21390819 | 0.76 | CNR2 (0.32) | JAK1 | |
| SCHEMBL21390815 | 0.76 | HDAC1 (0.33) | PDE10AJAK1TNFLITAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183148-A1 | KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE | KNOPP BIOSCIENCES LLC (US) | 2019-09-26 | — | — | WO | disclosed |