Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACSS2 | Q9NR19 | 6/20 | 0.43 |
| ▸ | CCR9 | P51686 | 2/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | ALB | P02768 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.31 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.31 |
| ▸ | TNKS | O95271 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.31 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.31 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | APEX1 | P27695 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21391037 | 0.97 | ACSS2 (0.42) | ACSS2CCR9SLC22A12ALBBRD4 | |
| SCHEMBL23132027 | 0.86 | ACSS2 (0.34) | ACSS2CCR9TLR8TLR7PDK1 | |
| SCHEMBL20110978 | 0.80 | ACSS2 (0.45) | ACSS2CCR9SLC22A12ALBPDK1 | |
| SCHEMBL18791849 | 0.80 | ACSS2 (0.45) | ACSS2CCR9SLC22A12ALBPDK1 | |
| SCHEMBL18791850 | 0.80 | ACSS2 (0.45) | ACSS2CCR9SLC22A12ALBPDK1 | |
| SCHEMBL21391043 | 0.78 | ACSS2 (0.41) | ACSS2CCR9SLC22A12ALBBRD4 | |
| SCHEMBL21390993 | 0.77 | HTT (0.31) | ACSS2AGTR1AGTR2 | |
| SCHEMBL21391062 | 0.76 | ACSS2 (0.33) | ACSS2 | |
| SCHEMBL21391052 | 0.76 | ACSS2 (0.36) | ACSS2BRD4 | |
| SCHEMBL21390959 | 0.75 | TRPV4 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183148-A1 | KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE | KNOPP BIOSCIENCES LLC (US) | 2019-09-26 | — | — | WO | disclosed |