Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 1/20 | 0.63 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.56 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.56 |
| ▸ | ACE | P12821 | 2/20 | 0.53 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.53 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.53 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.53 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.53 |
| ▸ | CTSG | P08311 | 2/20 | 0.53 |
| ▸ | CMA1 | P23946 | 2/20 | 0.53 |
| ▸ | PYGL | P06737 | 1/20 | 0.52 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.51 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18228675 | 1.00 | FPR2 (0.63) | FPR2ITGB3ITGA2BACEPLAAT3 | |
| SCHEMBL21959116 | 0.93 | FPR2 (0.56) | FPR2ITGB3ITGA2BACEPLAAT3 | |
| SCHEMBL18228915 | 0.93 | FPR2 (0.56) | FPR2ITGB3ITGA2BACEPLAAT3 | |
| SCHEMBL21959498 | 0.92 | FPR2 (0.53) | FPR2ITGB3ITGA2BACEPLAAT3 | |
| SCHEMBL18228876 | 0.92 | FPR2 (0.53) | FPR2ITGB3ITGA2BACEPLAAT3 | |
| SCHEMBL21959687 | 0.87 | KMT2A (0.56) | FPR2ITGB3ITGA2BPYGLCA2 | |
| SCHEMBL18228779 | 0.87 | KMT2A (0.56) | FPR2ITGB3ITGA2BPYGLCA2 | |
| SCHEMBL4153101 | 0.86 | ITGB3 (0.65) | ITGB3ITGA2BACECTSGCMA1 | |
| SCHEMBL4153095 | 0.86 | ITGB3 (0.65) | ITGB3ITGA2BACECTSGCMA1 | |
| SCHEMBL5458748 | 0.86 | ITGB3 (0.65) | ITGB3ITGA2BACECTSGCMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107531653-B | Novel difluoroketoamide derivatives | 豪夫迈·罗氏有限公司 | 2021-10-19 | — | — | CN | disclosed |
| US-10428108-B2 | Difluoroketamide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2019-10-01 | — | — | US | disclosed |
| CN-107531653-A | Novel difluoroketoamide derivatives | 豪夫迈·罗氏有限公司 | 2018-01-02 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10428108-B2 | Difluoroketamide derivatives | PRMT9, CDK9, FLT3 | FPR2 2549/4885ITGB3 2630/4885ITGA2B 2361/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.