Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21393588 | 0.83 | ALDH1A1 (0.41) | KDM4EALDH1A1ADORA3ADORA2AADORA2B | |
| SCHEMBL21363587 | 0.80 | ALDH1A1 (0.39) | KDM4EALDH1A1ADORA3ADORA2AADORA2B | |
| SCHEMBL22477705 | 0.80 | ALDH1A1 (0.39) | KDM4EALDH1A1ADORA3ADORA2AADORA2B | |
| SCHEMBL22477732 | 0.78 | ALDH1A1 (0.38) | KDM4EALDH1A1ADORA3ADORA2AADORA2B | |
| SCHEMBL25165851 | 0.73 | KDM4E (0.41) | KDM4EALDH1A1ADORA3ADORA2AADORA2B | |
| SCHEMBL30814728 | 0.70 | TLR8 (0.39) | ALDH1A1ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL26155930 | 0.70 | QTRT1 (0.42) | KDM4EALDH1A1GLAHSD17B10LMNA | |
| SCHEMBL4402726 | 0.68 | KMT2A (0.41) | KDM4EALDH1A1PRMT5CYP1A2POLB | |
| SCHEMBL18255988 | 0.68 | GRM4 (0.46) | KDM4EALDH1A1ADORA3ADORA2AADORA2B | |
| SCHEMBL21363488 | 0.66 | ALDH1A1 (0.41) | ALDH1A1ADORA2AADORA1TRPA1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019182925-A1 | OXADIAZOLE TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS | GENENTECH, INC. (US) | 2019-09-26 | — | — | WO | disclosed |