Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | BPTF | Q12830 | 1/20 | 0.31 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.30 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21393582 | 0.83 | KDM4E (0.49) | ALDH1A1ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL22477732 | 0.78 | ALDH1A1 (0.38) | ALDH1A1ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL22477705 | 0.78 | ALDH1A1 (0.39) | ALDH1A1ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL21363587 | 0.78 | ALDH1A1 (0.39) | ALDH1A1ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL30814728 | 0.68 | TLR8 (0.39) | ALDH1A1ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL26155930 | 0.68 | QTRT1 (0.42) | ALDH1A1KDM4ELMNA | |
| SCHEMBL9466617 | 0.67 | ADORA2A (0.38) | ALDH1A1ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL25165851 | 0.65 | KDM4E (0.41) | ALDH1A1ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL21363488 | 0.63 | ALDH1A1 (0.41) | ALDH1A1ADORA2AADORA1TRPA1CYP1A2 | |
| SCHEMBL4402726 | 0.63 | KMT2A (0.41) | ALDH1A1CYP1A2POLBCYP3A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019182925-A1 | OXADIAZOLE TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS | GENENTECH, INC. (US) | 2019-09-26 | — | — | WO | disclosed |