Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.40 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | HTR1F | P30939 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21394479 | 0.82 | RAB9A (0.46) | TSHRNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL21394512 | 0.81 | TSHR (0.53) | TSHRNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL21394641 | 0.80 | TSHR (0.47) | TSHRNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL29359147 | 0.80 | TSHR (0.47) | TSHRNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL29356991 | 0.80 | TSHR (0.47) | TSHRNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL21394809 | 0.80 | TSHR (0.47) | TSHRNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL21395157 | 0.74 | CYP3A4 (0.47) | TSHRL3MBTL1GRM5 | |
| SCHEMBL29357109 | 0.74 | TSHR (0.44) | TSHRNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL21394572 | 0.74 | TSHR (0.44) | TSHRNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL21394993 | 0.73 | NTRK1 (0.43) | TSHRNPC1RAB9ASMN1; SMN2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020198026-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-10-01 | — | — | WO | disclosed |
| WO-2019183587-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2019-09-26 | — | — | WO | disclosed |