SCHEMBL21396762

SCHEMBL21396762

N#Cc1ccc(-n2c3ccccc3c3ccccc32)c(-c2cccnc2-n2c3ccccc3c3cc(N(c4ccccc4)c4ccccc4)ccc32)c1

nearest known ligand 0.35

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
RORC P51449 3/20 0.35
DDB1 Q16531 1/20 0.33
CRBN Q96SW2 1/20 0.33
PTGER4 P35408 2/20 0.32
GABRA1 P14867 1/20 0.31
GABRG2 P18507 1/20 0.31
GABRB3 P28472 1/20 0.31
GABRA5 P31644 1/20 0.31
GABRA3 P34903 1/20 0.31
GABRA2 P47869 1/20 0.31
EGFR P00533 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21396759 1.00 RORC (0.35) RORCDDB1CRBNPTGER4GABRA1
SCHEMBL18361189 0.89 RORC (0.41) RORCPTGER4GABRA1GABRG2GABRB3
SCHEMBL21397014 0.89 DDB1 (0.37) DDB1CRBNPTGER4GABRA1GABRG2
SCHEMBL18374183 0.89 RORC (0.41) RORCPTGER4GABRA1GABRG2GABRB3
SCHEMBL17952746 0.86 KDM4E (0.33)
SCHEMBL18360983 0.85 GABRA1 (0.37) RORCGABRA1GABRG2GABRB3GABRA5
SCHEMBL21396968 0.85 DDB1 (0.36) RORCDDB1CRBNPTGER4EGFR
SCHEMBL21396661 0.85 DDB1 (0.36) RORCDDB1CRBNPTGER4EGFR
SCHEMBL18360982 0.84 RORC (0.39) RORCPTGER4GABRA1GABRG2GABRB3
SCHEMBL21396688 0.83 DDB1 (0.34) DDB1CRBNPTGER4GABRA1GABRG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3543230-B1 ORGANIC ELECTROLUMINESCENCE DEVICE AND POLYCYCLIC COMPOUND FOR ORGANIC ELECTROLUMINESCENCE DEVICE SAMSUNG DISPLAY CO LTD (KR) 2021-05-05 EP disclosed
US-20190296247-A1 ORGANIC ELECTROLUMINESCENCE DEVICE AND POLYCYCLIC COMPOUND FOR ORGANIC ELECTROLUMINESCENCE DEVICE SAMSUNG DISPLAY CO., LTD. (KR) 2019-09-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190296247-A1 ORGANIC ELECTROLUMINESCENCE DEVICE AND POLYCYCLIC COMPOUND FOR ORGANIC ELECTROLUMINESCENCE DEVICE SLC25A21, SLCO4C1, SLC18A1 RORC 3068/4885DDB1 2216/4885CRBN 4246/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.