Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.51 |
| ▸ | CNR1 | P21554 | 2/20 | 0.46 |
| ▸ | GRM5 | P41594 | 2/20 | 0.43 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.42 |
| ▸ | XDH | P47989 | 2/20 | 0.41 |
| ▸ | FNTA | P49354 | 1/20 | 0.41 |
| ▸ | FNTB | P49356 | 1/20 | 0.41 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24668349 | 0.83 | PDE2A (0.46) | MAOBCNR1 | |
| SCHEMBL20571893 | 0.78 | MAOB (0.44) | MAOBCNR1GRM5SQORGABRG2 | |
| SCHEMBL30529379 | 0.78 | MAOB (0.44) | MAOBCNR1GRM5SQORGABRG2 | |
| SCHEMBL3432981 | 0.78 | L3MBTL1 (0.47) | XDHGABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL24497447 | 0.76 | PKM (0.45) | GRM5 | |
| SCHEMBL24497448 | 0.76 | PKM (0.42) | MAOBGRM5GABRG2GABRB3GABRA5 | |
| SCHEMBL3803814 | 0.75 | GAA (0.39) | XDH | |
| SCHEMBL11994824 | 0.75 | XDH (0.40) | XDH | |
| SCHEMBL1008560 | 0.73 | KCNH2 (0.52) | MAOBGRM5 | |
| SCHEMBL2959124 | 0.73 | GABRA5 (0.55) | MAOBGRM5SQORGABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183367-A1 | SHP2 PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2019-09-26 | — | — | WO | disclosed |