Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 18/20 | 0.61 |
| ▸ | CDK2 | P24941 | 18/20 | 0.61 |
| ▸ | CCNA1 | P78396 | 18/20 | 0.61 |
| ▸ | RET | P07949 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2735393 | 0.78 | CCNA2 (0.54) | CCNA2CDK2CCNA1 | |
| SCHEMBL18642904 | 0.73 | RET (0.66) | CCNA2CDK2CCNA1RET | |
| SCHEMBL5867732 | 0.70 | CCNA2 (0.62) | CCNA2CDK2CCNA1 | |
| SCHEMBL5867628 | 0.70 | CCNA2 (0.63) | CCNA2CDK2CCNA1 | |
| SCHEMBL5867707 | 0.70 | CCNA2 (0.82) | CCNA2CDK2CCNA1 | |
| SCHEMBL5867638 | 0.70 | CCNA2 (0.71) | CCNA2CDK2CCNA1 | |
| SCHEMBL4314346 | 0.70 | CCNA2 (1.00) | CCNA2CDK2CCNA1 | |
| SCHEMBL5867715 | 0.70 | CCNA2 (0.70) | CCNA2CDK2CCNA1 | |
| SCHEMBL213391 | 0.69 | ALDH1A1 (0.76) | — | |
| SCHEMBL7919995 | 0.69 | CCNA2 (1.00) | CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088767-B2 | JAK-2 modulators and methods of use | EXELIXIS, INC. (US) | 2012-01-03 | — | — | US | disclosed |