Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21427791 | 1.00 | ALDH1A1 (0.54) | ALDH1A1NPC1TDP1CYP3A4CYP2C9 | |
| SCHEMBL17268009 | 0.86 | ALDH1A1 (0.59) | ALDH1A1CYP3A4CYP2C9PKMCYP2C19 | |
| SCHEMBL21427542 | 0.82 | EPHX1 (0.56) | ALDH1A1CYP2C19KMT2AHPGDFKBP1A | |
| SCHEMBL21427538 | 0.82 | EPHX1 (0.56) | ALDH1A1CYP2C19KMT2AHPGDFKBP1A | |
| SCHEMBL21427537 | 0.82 | P2RX7 (0.68) | P2RX7 | |
| SCHEMBL21427541 | 0.82 | P2RX7 (0.68) | P2RX7 | |
| SCHEMBL30568965 | 0.82 | P2RX7 (0.68) | P2RX7 | |
| SCHEMBL21427530 | 0.80 | P2RX7 (0.56) | P2RX7 | |
| SCHEMBL21427529 | 0.80 | P2RX7 (0.56) | P2RX7 | |
| SCHEMBL14299315 | 0.78 | P2RX7 (0.70) | ALDH1A1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11919854-B2 | P2RX7 modulators in therapy | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2024-03-05 | — | — | US | disclosed |
| CN-112512520-B | P2RX7 modulators in therapy | 国家科学研究中心 | 2023-10-24 | — | — | CN | disclosed |
| EP-3773557-A1 | P2RX7 MODULATORS IN THERAPY | Centre national de la recherche scientifique (FR) | 2021-02-17 | — | — | EP | disclosed |
| US-20210017131-A1 | P2RX7 MODULATORS IN THERAPY | JUNIA (FR) | 2021-01-21 | — | — | US | disclosed |
| WO-2019185868-A1 | P2RX7 MODULATORS IN THERAPY | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2019-10-03 | — | — | WO | disclosed |
| WO-2019185868-A1 | P2RX7 MODULATORS IN THERAPY | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2019-10-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210017131-A1 | P2RX7 MODULATORS IN THERAPY | P2RX3, P2RX7, P2RX2 | ALDH1A1 1188/4885NPC1 907/4885TDP1 2571/4885 |
| US-11919854-B2 | P2RX7 modulators in therapy | P2RX7, P2RX2, P2RX1 | ALDH1A1 1230/4885NPC1 1097/4885TDP1 2519/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.