Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | STS | P08842 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15416696 | 1.00 | EPHX1 (0.41) | EPHX1HPGDGPR119RECQLSTS | |
| SCHEMBL17781920 | 0.91 | APLNR (0.37) | EPHX1HPGDGPR119STSHSD17B10 | |
| SCHEMBL29083228 | 0.84 | EPHX1 (0.45) | EPHX1HPGDGPR119RECQLSTS | |
| SCHEMBL26171864 | 0.84 | EPHX1 (0.45) | EPHX1HPGDGPR119RECQLSTS | |
| SCHEMBL20583811 | 0.83 | KDM4E (0.55) | GPR119STSKDM4EPKMKMT2A | |
| SCHEMBL21649154 | 0.82 | EPHX1 (0.46) | EPHX1HPGDGPR119RECQLSTS | |
| SCHEMBL31734338 | 0.82 | EPHX1 (0.46) | EPHX1HPGDGPR119RECQLSTS | |
| SCHEMBL30368229 | 0.77 | STS (0.49) | GPR119STSKDM4EMAPTTHRB | |
| SCHEMBL31433654 | 0.77 | HPGD (0.44) | EPHX1HPGDGPR119RECQLSTS | |
| SCHEMBL31433665 | 0.77 | HPGD (0.44) | EPHX1HPGDGPR119RECQLSTS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3773576-A1 | CEREBLON BINDERS FOR THE DEGRADATION OF IKAROS | C4 Therapeutics, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |
| WO-2019191112-A1 | CEREBLON BINDERS FOR THE DEGRADATION OF IKAROS | C4 THERAPEUTICS, INC. (US) | 2019-10-03 | — | — | WO | disclosed |