Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 4/20 | 0.49 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.49 |
| ▸ | PTGER3 | P43115 | 4/20 | 0.49 |
| ▸ | PTGER2 | P43116 | 4/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 4/20 | 0.41 |
| ▸ | GSK3B | P49841 | 3/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8853244 | 0.91 | KDM4E (0.43) | PTGER1PTGER4PTGER3PTGER2PARP1 | |
| SCHEMBL8693038 | 0.86 | KDM4E (0.44) | PTGER1PTGER4PTGER3PTGER2PARP1 | |
| SCHEMBL5970012 | 0.84 | GSK3B (0.50) | PARP1KDM4EALDH1A1GAAHPGD | |
| SCHEMBL8853131 | 0.83 | KDM4E (0.47) | PARP1KDM4EALDH1A1GAAHPGD | |
| SCHEMBL8853391 | 0.83 | ALDH1A1 (0.42) | PARP1KDM4EALDH1A1GAAHPGD | |
| SCHEMBL1424202 | 0.81 | KDM4E (0.45) | PARP1KDM4EALDH1A1GAAHPGD | |
| Bicarbonate SCHEMBL29212760 | 0.80 | KDM4E (0.46) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL31474424 | 0.80 | ALDH1A1 (0.49) | PARP1KDM4EALDH1A1GAAHPGD | |
| Water SCHEMBL10733874 | 0.80 | KDM4E (0.44) | PARP1KDM4EALDH1A1GAAHPGD | |
| SCHEMBL11015946 | 0.80 | GSK3B (0.45) | PARP1KDM4EALDH1A1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148397-B2 | 5-HT7 receptor antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2012-04-03 | — | — | US | disclosed |
| WO-2010042851-A1 | ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS | ACHAOGEN, INC. (US) | 2010-04-15 | — | — | WO | disclosed |
| US-20090088450-A1 | 5-ht7 receptor antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2009-04-02 | — | — | US | disclosed |
| EP-1778641-A1 | 5-HT7 RECEPTOR ANTAGONISTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-05-02 | — | — | EP | disclosed |
| US-7211584-B2 | 5-HT7 receptor ligands | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-05-01 | — | — | US | disclosed |
| EP-1630159-A1 | 5-HT7 receptor antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2006-03-01 | — | — | EP | disclosed |
| US-20060040977-A1 | 5-HT7 receptor ligands | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2006-02-23 | — | — | US | disclosed |
| WO-2006018309-A1 | 5-HT7 RECEPTOR ANTAGONISTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2006-02-23 | — | — | WO | disclosed |
| US-5688434-A | BLEACHING TEXTILES BY APPLYING BLEACHING AGENT | AUSIMONT S.P.A. (IT) | 1997-11-18 | — | — | US | disclosed |
| US-5575947-A | BLEACH | AUSIMONT S.R.L. (IT) | 1996-11-19 | — | — | US | disclosed |
| US-5567411-A | ADMINISTERING TO A WARM-BLOODED ANIMAL TO OBTAIN A MAGNETIC RESONANCE IMAGE OF SUBJECT | STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF OREGON (US) | 1996-10-22 | — | — | US | disclosed |
| US-5520844-A | Imide-aromatic peroxyacids as bleaching agents | AUSIMONT S.P.A. (IT) | 1996-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090088450-A1 | 5-ht7 receptor antagonists | HTR7, HTR1A, HTR5A | PTGER1 191/4885PTGER4 266/4885PTGER3 232/4885 |
| US-20060040977-A1 | 5-HT7 receptor ligands | HTR7, HTR1A, HTR5A | PTGER1 224/4885PTGER4 302/4885PTGER3 265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.