Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.37 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21416769 | 0.79 | NPSR1 (0.43) | NPC1RAB9AKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL20779328 | 0.76 | KMT2A (0.42) | NPC1RAB9AKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL21991721 | 0.73 | RAB9A (0.44) | NPC1RAB9AKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL23592890 | 0.71 | ALDH1A1 (0.40) | KMT2AMAPTHDAC1HDAC7HDAC8 | |
| SCHEMBL25721410 | 0.70 | HDAC6 (0.67) | NPC1RAB9AKMT2ATRPV1MAPT | |
| SCHEMBL22746195 | 0.70 | NPC1 (0.63) | NPC1RAB9AKMT2ATRPV1MAPT | |
| SCHEMBL21588673 | 0.70 | HDAC6 (0.67) | NPC1RAB9AKMT2ATRPV1MAPT | |
| SCHEMBL24137699 | 0.70 | NPC1 (0.42) | NPC1RAB9AKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL22746196 | 0.70 | NPC1 (0.58) | NPC1RAB9AKMT2ATRPV1MAPT | |
| SCHEMBL21021669 | 0.69 | MAPT (0.45) | NPC1RAB9AKMT2ATRPV1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2019-10-02 | — | — | EP | disclosed |