Sugi Predict

Sugi Predict / Compounds / SCHEMBL2143294

SCHEMBL2143294

SCHEMBL2143294

Cc1cc(C)nc(C#N)n1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 3/20 0.45
▸ KCNH2 Q12809 2/20 0.42
▸ GPR119 Q8TDV5 2/20 0.42
▸ MEN1 O00255 1/20 0.42
▸ KMT2A Q03164 1/20 0.42
▸ POLB P06746 1/20 0.42
▸ APOBEC3G Q9HC16 1/20 0.42
▸ LMNA P02545 2/20 0.38
▸ HTT P42858 2/20 0.38
▸ TSHR P16473 1/20 0.38
▸ TDP1 Q9NUW8 1/20 0.38
▸ F2 P00734 1/20 0.38
▸ MAPK1 P28482 1/20 0.38
▸ GRM5 P41594 1/20 0.38
▸ ALDH1A1 P00352 4/20 0.37
▸ RECQL P46063 2/20 0.37
▸ HPGD P15428 2/20 0.37
▸ HSD17B10 Q99714 1/20 0.37
▸ L3MBTL1 Q9Y468 1/20 0.36
▸ GAA P10253 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21614634 0.85 KDM4E (0.39) KDM4EKCNH2GPR119MEN1KMT2A
SCHEMBL1187259 0.84 KDM4E (0.38) KDM4EKCNH2GPR119MEN1KMT2A
SCHEMBL18297112 0.84 LMNA (0.41) KDM4EKCNH2GPR119MEN1KMT2A
SCHEMBL10505005 0.80 RECQL (0.49) KDM4EKCNH2GPR119MEN1KMT2A
SCHEMBL11960329 0.80 HTT (0.38) KDM4EKCNH2GPR119MEN1KMT2A
SCHEMBL18297060 0.80 MEN1 (0.46) KDM4EKCNH2GPR119MEN1KMT2A
SCHEMBL29957156 0.80 GPR119 (0.36) KDM4EKCNH2GPR119MEN1KMT2A
SCHEMBL25992531 0.79 KDM4E (0.40) KDM4EKCNH2GPR119MEN1KMT2A
SCHEMBL1514752 0.77 CTSK (0.53) KDM4EKCNH2GPR119MEN1KMT2A
SCHEMBL1509844 0.76 CTSK (0.62) KDM4EMEN1KMT2APOLBLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119490498-A Cyanopyrimidine derivative organic compound, application thereof, perovskite solar cell and organic electroluminescent device 北京绿人科技有限责任公司 2025-02-21 — — CN disclosed
EP-4326257-A1 AZETIDINYL-ACETAMIDES AS CXCR7 INHIBITORS ChemoCentryx, Inc. (US) 2024-02-28 — — EP disclosed
US-20220348568-A1 AZETIDINYL-ACETAMIDES AS CXCR7 INHIBITORS INC., CHEMOCENTRYX 2022-11-03 — — US disclosed
WO-2022225832-A1 AZETIDINYL-ACETAMIDES AS CXCR7 INHIBITORS CHEMOCENTRYX, INC. (US) 2022-10-27 — — WO disclosed
US-9309240-B2 Pyrazolopyridine compounds, compositions and methods of use GENENTECH, INC. (US) 2016-04-12 — — US disclosed
EP-2640722-B1 PYRAZOLOPYRIDINES AND THEIR USE AS TYK2 INHIBITORS HOFFMANN LA ROCHE (CH) 2015-11-04 — — EP disclosed
WO-2015091584-A1 THIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND THEIR USE AS TYK2 KINASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2015-06-25 — — WO disclosed
US-20140206702-A1 IMIDAZOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE GENENTECH, INC. (US) 2014-07-24 — — US disclosed
US-20140171408-A1 AZABENZOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE GENENTECH, INC. (US) 2014-06-19 — — US disclosed
US-8722688-B2 Compounds for the treatment of hepatitis C BRISTOL-MYERS SQUIBB COMPANY (US) 2014-05-13 — — US disclosed
US-8148382-B2 Compounds for the treatment of hepatitis C BRISTOL-MYERS SQUIBB COMPANY (US) 2012-04-03 — — US disclosed
US-20110256099-A1 Compounds for the Treatment of Hepatitis C BRISTOL-MYERS SQUIBB COMPANY 2011-10-20 — — US disclosed
WO-2011112191-A1 COMPOUNDS FOR THE TREATMENT OF HEPATITIS C BRISTOL-MYERS SQUIBB COMPANY (US) 2011-09-15 — — WO disclosed
US-7994171-B2 Compounds for the treatment of hepatitis C BRISTOL-MYERS SQUIBB COMPANY (US) 2011-08-09 — — US disclosed
US-20100249094-A1 Compounds for the Treatment of Hepatitis C BRISTOL-MYERS SQUIBB COMPANY 2010-09-30 — — US disclosed
US-20090072727-A1 ORGANIC ELECTROLUMINESCENCE DEVICE FUJIFILM CORPORATION (JP) 2009-03-19 — — US disclosed
US-7402548-B2 Benzoxazole compounds, process for producing the same and herbicides KYOYU AGRI CO., LTD. (JP) 2008-07-22 — — US disclosed
US-7402548-B2 Benzoxazole compounds, process for producing the same and herbicides KYOYU AGRI CO., LTD. (JP) 2008-07-22 — — US disclosed
EP-1637525-B1 Benzoxazole compound, process for producing the same, and herbicides KYOYU AGRI CO LTD (JP) 2007-12-19 — — EP disclosed
US-5236923-A Chemical intermediates, fungicides, pesticides BAYER AKTIENGESELLSCHAFT (DE) 1993-08-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140206702-A1 IMIDAZOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE P2RX6, P2RY6, CYP2D6 KDM4E 3349/4885KCNH2 276/4885GPR119 97/4885
US-20100249094-A1 Compounds for the Treatment of Hepatitis C HAVCR2, HCCS, SLC10A1 KDM4E 4218/4885KCNH2 3814/4885GPR119 2020/4885
US-20220348568-A1 AZETIDINYL-ACETAMIDES AS CXCR7 INHIBITORS CXCR1, CXCR5, CXCR6 KDM4E 3817/4885KCNH2 2084/4885GPR119 109/4885
US-20110256099-A1 Compounds for the Treatment of Hepatitis C HAVCR2, HCCS, SLC10A1 KDM4E 4218/4885KCNH2 3814/4885GPR119 2020/4885
US-20140171408-A1 AZABENZOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE F12, CHRM1, NPY1R KDM4E 2481/4885KCNH2 2565/4885GPR119 500/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.