Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | EGLN1 | Q9GZT9 | 15/20 | 0.47 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2143911 | 0.82 | ALDH1A1 (0.57) | ALDH1A1EGLN1BCHE | |
| SCHEMBL2143974 | 0.80 | ALDH1A1 (0.55) | ALDH1A1EGLN1RCE1HCRTR2BCHE | |
| SCHEMBL2143834 | 0.80 | ALDH1A1 (0.51) | ALDH1A1EGLN1HCRTR2BCHE | |
| SCHEMBL2143947 | 0.78 | ALDH1A1 (0.61) | ALDH1A1EGLN1 | |
| SCHEMBL2143987 | 0.77 | ALDH1A1 (0.51) | ALDH1A1EGLN1HCRTR2BCHE | |
| SCHEMBL2143797 | 0.76 | ALDH1A1 (0.60) | ALDH1A1EGLN1 | |
| SCHEMBL2143789 | 0.76 | ALDH1A1 (0.50) | ALDH1A1EGLN1RCE1HCRTR2BCHE | |
| SCHEMBL2143830 | 0.76 | ALDH1A1 (0.52) | ALDH1A1EGLN1HCRTR2BCHE | |
| SCHEMBL2143736 | 0.75 | CTSB (0.60) | ALDH1A1EGLN1BCHE | |
| SCHEMBL2143842 | 0.75 | HSP90AA1 (0.53) | ALDH1A1EGLN1HCRTR2BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519505-B1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM SA (LU) | 2015-05-27 | — | — | EP | claimed |
| US-8729098-B2 | Tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof | POLICHEM SA (LU) | 2014-05-20 | — | — | US | claimed |
| US-20120309751-A1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM SA (LU) | 2012-12-06 | — | — | US | claimed |
| EP-2519505-A1 | NEW TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | Polichem SA (LU) | 2012-11-07 | — | — | EP | claimed |
| EP-2345643-A1 | New tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof | POLICHEM S.A. (LU) | 2011-07-20 | — | — | EP | claimed |
| WO-2011080264-A1 | NEW TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM S.A. (LU) | 2011-07-07 | — | — | WO | claimed |
| EP-2519505-B1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM SA (LU) | 2015-05-27 | — | — | EP | disclosed |
| EP-2519505-B1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM SA (LU) | 2015-05-27 | — | — | EP | disclosed |
| US-8729098-B2 | Tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof | POLICHEM SA (LU) | 2014-05-20 | — | — | US | disclosed |
| US-8729098-B2 | Tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof | POLICHEM SA (LU) | 2014-05-20 | — | — | US | disclosed |
| US-8729098-B2 | Tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof | POLICHEM SA (LU) | 2014-05-20 | — | — | US | disclosed |
| US-20120309751-A1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM SA (LU) | 2012-12-06 | — | — | US | disclosed |
| US-20120309751-A1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM SA (LU) | 2012-12-06 | — | — | US | disclosed |
| US-20120309751-A1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM SA (LU) | 2012-12-06 | — | — | US | disclosed |
| EP-2519505-A1 | NEW TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | Polichem SA (LU) | 2012-11-07 | — | — | EP | disclosed |
| EP-2345643-A1 | New tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof | POLICHEM S.A. (LU) | 2011-07-20 | — | — | EP | disclosed |
| WO-2011080264-A1 | NEW TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM S.A. (LU) | 2011-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120309751-A1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | TUBA8, SUCLG1, TUBB8 | ALDH1A1 931/4885EGLN1 777/4885RCE1 753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.