Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | PANK3 | Q9H999 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | NPY2R | P49146 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6784455 | 0.85 | HIF1A (0.54) | MAPTALDH1A1KMT2AGFERKDM4E | |
| SCHEMBL254670 | 0.84 | HIF1A (0.53) | MAPTALDH1A1KMT2AGFERKDM4E | |
| SCHEMBL21435774 | 0.83 | MAPT (0.57) | L3MBTL1MAPTALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL10288811 | 0.82 | PANK3 (0.58) | L3MBTL1MAPTALDH1A1KMT2AGFER | |
| SCHEMBL5235731 | 0.78 | PANK3 (0.54) | L3MBTL1MAPTALDH1A1KMT2APOLB | |
| SCHEMBL3025580 | 0.76 | ALDH1A1 (0.63) | L3MBTL1MAPTALDH1A1KMT2APOLB | |
| SCHEMBL10085476 | 0.75 | RAB9A (0.53) | MAPTALDH1A1KMT2APOLBKDM4E | |
| SCHEMBL19212202 | 0.75 | PANK3 (0.49) | L3MBTL1MAPTALDH1A1KMT2AGFER | |
| SCHEMBL19212221 | 0.75 | GFER (0.45) | L3MBTL1MAPTALDH1A1GFERPANK3 | |
| SCHEMBL632352 | 0.75 | L3MBTL1 (0.73) | L3MBTL1MAPTALDH1A1POLBGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3774768-A1 | SUBSTITUTED PYRAZOLE DERIVATIVES AS SELECTIVE CDK12/13 INHIBITORS | Aurigene Discovery Technologies Limited (IN) | 2021-02-17 | — | — | EP | disclosed |
| WO-2019193509-A1 | SUBSTITUTED PYRAZOLE DERIVATIVES AS SELECTIVE CDK12/13 INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2019-10-10 | — | — | WO | disclosed |