Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.38 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.38 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.38 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.38 |
| ▸ | VNN1 | O95497 | 2/20 | 0.37 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23025737 | 0.84 | HDAC3 (0.38) | HDAC3HDAC1HDAC2HDAC6VNN1 | |
| SCHEMBL15829268 | 0.81 | ALDH1A1 (0.38) | LCKBTKUSP2ALDH1A1CYP1A2 | |
| SCHEMBL21984718 | 0.79 | SIGMAR1 (0.42) | LCKBTKHDAC3HDAC1HDAC2 | |
| SCHEMBL19477233 | 0.79 | SIGMAR1 (0.42) | LCKBTKHDAC3HDAC1HDAC2 | |
| SCHEMBL24786393 | 0.79 | ESR1 (0.43) | HDAC3HDAC1HDAC2HDAC6VNN1 | |
| Hydrochloric Acid SCHEMBL28378834 | 0.78 | SIGMAR1 (0.41) | LCKBTKHDAC3HDAC1HDAC2 | |
| Hydrochloric Acid SCHEMBL28378836 | 0.78 | SIGMAR1 (0.41) | LCKBTKHDAC3HDAC1HDAC2 | |
| SCHEMBL18881735 | 0.77 | AOC3 (0.41) | HDAC3HDAC1HDAC2HDAC6HPGD | |
| SCHEMBL25075225 | 0.76 | SYK (0.44) | BTKHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL15424474 | 0.76 | ULK1 (0.41) | HDAC3HDAC1HDAC2HDAC6USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3630775-B1 | 6-5 FUSED RINGS AS C5a INHIBITORS | CHEMOCENTRYX INC (US) | 2022-12-14 | — | — | EP | disclosed |
| WO-2019195159-A1 | PRODRUGS OF FUSED-BICYCLIC C5aR ANTAGONISTS | CHEMOCENTRYX, INC. (US) | 2019-10-10 | — | — | WO | disclosed |