SCHEMBL21448045

SCHEMBL21448045

Nc1nc2c(ncn2[C@@H]2O[C@H](COP(=O)(O)OC3C(O)[C@H](n4cnc5c(N)ncnc54)O[C@@H]3CO)C(OC[PH](=O)O)C2O)c(=O)[nH]1

nearest known ligand 0.61

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ RNASEL Q05823 13/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21448240 1.00 RNASEL (0.61) RNASEL
SCHEMBL21511256 1.00 RNASEL (0.61) RNASEL
SCHEMBL21454910 0.97 RNASEL (0.63) RNASEL
SCHEMBL21454903 0.97 RNASEL (0.63) RNASEL
SCHEMBL21454871 0.97 RNASEL (0.63) RNASEL
SCHEMBL21454866 0.97 RNASEL (0.63) RNASEL
SCHEMBL21448241 0.96 RNASEL (0.57) RNASEL
SCHEMBL21511245 0.96 RNASEL (0.57) RNASEL
SCHEMBL21448247 0.96 RNASEL (0.57) RNASEL
SCHEMBL21454768 0.96 RNASEL (0.66) RNASEL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190322696-A1 3'3'-CYCLIC DINUCLEOTIDES INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR,V.V.I. (CZ) 2019-10-24 — — US disclosed
WO-2019193543-A1 3'3'-CYCLIC DINUCLEOTIDES INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. (CZ) 2019-10-10 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190322696-A1 3'3'-CYCLIC DINUCLEOTIDES STING1, CGAS, MAVS RNASEL 1954/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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