Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | CTSE | P14091 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21452162 | 0.85 | TAS1R3 (0.38) | KDM1A | |
| SCHEMBL21452371 | 0.82 | CCR2 (0.41) | MEN1KMT2ADDB1CRBNMAPT | |
| SCHEMBL23003321 | 0.78 | DDB1 (0.38) | DDB1CRBNGRIN2BBACE1SLC6A4 | |
| SCHEMBL21452493 | 0.77 | GRIN1 (0.46) | KDM1AMEN1KMT2ASIGMAR1GRIN2B | |
| SCHEMBL11189378 | 0.76 | MEN1 (0.43) | KDM1AMEN1KMT2AMAPTADAM17 | |
| SCHEMBL21452404 | 0.74 | MEN1 (0.42) | KDM1AMEN1KMT2ASIGMAR1ADAM17 | |
| SCHEMBL11186880 | 0.74 | MAPT (0.44) | MEN1KMT2AMAPTADAM17GRIN2B | |
| SCHEMBL21452127 | 0.74 | CHRM2 (0.38) | MEN1KMT2ASIGMAR1DDB1CRBN | |
| SCHEMBL11543846 | 0.73 | ALDH1A1 (0.41) | KDM1AMEN1KMT2AMAPTADAM17 | |
| SCHEMBL28255039 | 0.72 | KDM1A (0.47) | KDM1AMEN1KMT2AADAM17ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3778579-A1 | AROMATIC COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF | Shanghai Jianhe Pharmaceutical & Technology Co. Ltd. (CN) | 2021-02-17 | — | — | EP | disclosed |
| WO-2019192602-A1 | AROMATIC COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF | 上海键合医药科技有限公司 | 2019-10-10 | — | — | WO | disclosed |