Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 3/20 | 0.39 |
| ▸ | BRD4 | O60885 | 3/20 | 0.37 |
| ▸ | BAZ2A | Q9UIF9 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | LIPC | P11150 | 1/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.34 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.34 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25078511 | 0.89 | ENPP2 (0.39) | JAK3JAK2ENPP2JAK1TYK2 | |
| SCHEMBL6937715 | 0.84 | JAK2 (0.42) | JAK3BRD4BAZ2AJAK2JAK1 | |
| SCHEMBL17918650 | 0.83 | ACHE (0.44) | ENPP2GAAKMT2ALMNAHTT | |
| SCHEMBL21566466 | 0.82 | LIPC (0.36) | JAK3BRD4BAZ2AJAK2JAK1 | |
| SCHEMBL21419214 | 0.82 | LIPC (0.36) | JAK3BRD4BAZ2AJAK2JAK1 | |
| SCHEMBL16401518 | 0.81 | HRH3 (0.39) | JAK3BRD4JAK2ENPP2JAK1 | |
| SCHEMBL1662611 | 0.81 | JAK3 (0.37) | JAK3BRD4BAZ2AJAK2JAK1 | |
| Hydrochloric Acid SCHEMBL28516962 | 0.81 | JAK3 (0.44) | JAK3BRD4BAZ2AJAK2JAK1 | |
| SCHEMBL23036822 | 0.79 | GABRA1 (0.38) | JAK3BRD4BAZ2AJAK2JAK1 | |
| SCHEMBL21285243 | 0.78 | SCD (0.46) | JAK3JAK2JAK1TYK2CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023235433-A1 | BICYCLIC INHIBITORS OF IRAK | RIGEL PHARMACEUTICALS, INC. (US) | 2023-12-07 | — | — | WO | disclosed |
| WO-2019195846-A1 | IMIDAZOPIPERAZINONE INHIBITORS OF TRANSCRIPTION ACTIVATING PROTEINS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2019-10-10 | — | — | WO | disclosed |