Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | GALR3 | O60755 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ether SCHEMBL330790 | 0.93 | TSHR (0.61) | TSHRALDH1A1LMNAHSD17B10CHRM2 | |
| Propylene Glycol SCHEMBL329889 | 0.89 | TSHR (0.56) | TSHRALDH1A1LMNAHSD17B10CHRM2 | |
| Di(Hydroxyethyl)Ether SCHEMBL597204 | 0.88 | TSHR (0.54) | TSHRALDH1A1LMNAHSD17B10CHRM2 | |
| Propane SCHEMBL27531646 | 0.87 | TSHR (0.82) | TSHRALDH1A1LMNAHSD17B10CHRM2 | |
| Triethylene Glycol SCHEMBL596542 | 0.86 | TSHR (0.52) | TSHRALDH1A1LMNAHSD17B10CHRM2 | |
| 2-Ethoxyethanol SCHEMBL125169 | 0.85 | TSHR (0.56) | TSHRALDH1A1LMNAHSD17B10CHRM2 | |
| Ether SCHEMBL3257210 | 0.84 | TSHR (0.50) | TSHRALDH1A1LMNAHSD17B10CHRM2 | |
| Alcohol SCHEMBL247964 | 0.84 | TSHR (0.78) | TSHRALDH1A1LMNAHSD17B10CHRM2 | |
| SCHEMBL21064874 | 0.84 | TSHR (1.00) | TSHRALDH1A1LMNACHRM2CHRM4 | |
| SCHEMBL19193 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12023409-B2 | Phosphodiesterase-4 inhibitor combinations, methods of making, and methods of use thereof | VK RESEARCH ASSOCIATES INC. (US) | 2024-07-02 | — | — | US | disclosed |
| US-20230043979-A1 | PHOSPHODIESTERASE-4 INHIBITOR COMBINATIONS, METHODS OF MAKING, AND METHODS OF USE THEREOF | VK Research Associates Inc | 2023-02-09 | — | — | US | disclosed |
| CN-114891366-A | Colorant, colored resin composition comprising the same, and color filter | 乐金显示有限公司 | 2022-08-12 | — | — | CN | disclosed |
| CN-114341232-A | Method for producing silicon-containing polymer composition | 日产化学株式会社 | 2022-04-12 | — | — | CN | disclosed |
| CN-113439223-A | Optical filter for solid-state imaging element and solid-state imaging element | 凸版印刷株式会社 | 2021-09-24 | — | — | CN | disclosed |
| US-20210275531-A1 | PHOSPHODIESTERASE-5 INHIBITOR COMBINATIONS, METHODS OF MAKING, AND METHODS OF USE THEREOF | VK Research Associates Inc | 2021-09-09 | — | — | US | disclosed |
| US-10426724-B2 | Antihistamine compositions, combinations, and use thereof | APTAPHARMA INC. (US) | 2019-10-01 | — | — | US | disclosed |
| US-20180338913-A1 | ANTIHISTAMINE COMPOSITIONS, COMBINATIONS, AND USE THEREOF | APTAPHARMA INC (US) | 2018-11-29 | — | — | US | disclosed |
| US-10064820-B2 | Antihistamine compositions, combinations, and use thereof | APTAPHARMA INC. (US) | 2018-09-04 | — | — | US | disclosed |
| US-20180092837-A1 | ANTIHISTAMINE COMPOSITIONS, COMBINATIONS, AND USE THEREOF | APTAPHARMA INC. | 2018-04-05 | — | — | US | disclosed |
| US-8497290-B2 | Thiocolchicine derivatives, method of making and methods of use thereof | TAKEDA PHARMACEUTICALS U.S.A., INC. (US) | 2013-07-30 | — | — | US | disclosed |
| US-20130053399-A1 | METHODS OF ADMINISTERING ANTIHISTAMINES | APTAPHARMA INC. | 2013-02-28 | — | — | US | disclosed |
| CN-102448930-A | Thiocolchicine derivatives, method of making and methods of use thereof | MUTUAL PHARMACEUTICAL CO | 2012-05-09 | — | — | CN | disclosed |
| US-20110184061-A1 | THIOCOLCHICINE AND COLCHICINE ANALOGS, METHODS OF MAKING AND METHODS OF USE THEREOF | MPC OLDCO, INC. | 2011-07-28 | — | — | US | disclosed |
| WO-2011091114-A2 | THIOCOLCHICINE AND COLCHICINE ANALOGS, METHODS OF MAKING AND METHODS OF USE THEREOF | MUTUAL PHARMACEUTICAL COMPANY, INC. (US) | 2011-07-28 | — | — | WO | disclosed |
| US-20110178180-A1 | DEUTERIUM-ENRICHED COLCHICINE, THIOCOLCHICINE, AND DERIVATIVES THEREOF; METHODS OF PREPARATION; AND USE THEREOF | MPC OLDCO, INC. | 2011-07-21 | — | — | US | disclosed |
| WO-2010138670-A2 | THIOCOLCHICINE DERIVATIVES, METHOD OF MAKING AND METHODS OF USE THEREOF | MUTUAL PHARMACEUTICAL COMPANY, INC. (US) | 2010-12-02 | — | — | WO | disclosed |
| US-20100305165-A1 | THIOCOLCHICINE DERIVATIVES, METHOD OF MAKING AND METHODS OF USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-02 | — | — | US | disclosed |
| EP-0804865-A1 | PRODUCTION OF ELECTRICAL CIRCUIT BOARDS | Coates Brothers PLC (GB) | 1997-11-05 | — | — | EP | disclosed |
| WO-1996022670-A1 | PRODUCTION OF ELECTRICAL CIRCUIT BOARDS | COATES BROTHERS PLC (GB) | 1996-07-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178180-A1 | DEUTERIUM-ENRICHED COLCHICINE, THIOCOLCHICINE, AND DERIVATIVES THEREOF; METHODS OF PREPARATION; AND USE THEREOF | MTPN, TNNC1, PDF | TSHR 2035/4885ALDH1A1 4483/4885LMNA 905/4885 |
| US-20100305165-A1 | THIOCOLCHICINE DERIVATIVES, METHOD OF MAKING AND METHODS OF USE THEREOF | TNNC1, TNNI3, TNNT2 | TSHR 1049/4885ALDH1A1 1790/4885LMNA 1706/4885 |
| US-20110184061-A1 | THIOCOLCHICINE AND COLCHICINE ANALOGS, METHODS OF MAKING AND METHODS OF USE THEREOF | TPMT, TNNC1, MTPN | TSHR 2212/4885ALDH1A1 3416/4885LMNA 1086/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.