Biphenyl

Biphenyl

SCHEMBL21467263

CC(C)(C)OC(C)(C)C.[SiH4].c1ccc(-c2ccccc2)cc1

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.50
MAPK1 P28482 2/20 0.40
SLC22A2 O15244 1/20 0.40
SLC22A1 O15245 1/20 0.40
SLC22A3 O75751 1/20 0.40
SLC6A4 P31645 1/20 0.40
KIF11 P52732 1/20 0.39
CYP1A2 P05177 2/20 0.38
HSD17B10 Q99714 2/20 0.38
TDP1 Q9NUW8 2/20 0.38
TAAR1 Q96RJ0 2/20 0.38
CYP3A4 P08684 1/20 0.38
NOTUM Q6P988 1/20 0.38
MMP3 P08254 1/20 0.38
BCL2L1 Q07817 1/20 0.38
ALOX15 P16050 1/20 0.37
MAPT P10636 2/20 0.36
CYP1A1 P04798 1/20 0.36
CYP1B1 Q16678 1/20 0.36
AKT1 P31749 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Biphenyl SCHEMBL1193167 0.97 ALDH1A1 (0.53) ALDH1A1MAPK1SLC22A2SLC22A1SLC22A3
Biphenyl SCHEMBL28173511 0.80 ALDH1A1 (0.53) ALDH1A1MAPK1SLC22A2SLC22A1SLC22A3
Biphenyl SCHEMBL2500006 0.79 ALDH1A1 (0.45) ALDH1A1MAPK1SLC22A2SLC22A1SLC22A3
Biphenyl SCHEMBL27745920 0.78 ALDH1A1 (0.69) ALDH1A1MAPK1SLC22A2SLC22A1SLC22A3
Biphenyl SCHEMBL27335451 0.78 ALDH1A1 (0.69) ALDH1A1MAPK1SLC22A2SLC22A1SLC22A3
Benzene SCHEMBL7448458 0.78 ALDH1A1 (0.36) ALDH1A1MAPK1TDP1ALOX15TSHR
Biphenyl SCHEMBL2304558 0.78 ALDH1A1 (0.50) ALDH1A1MAPK1SLC22A2SLC22A1SLC22A3
Toluene SCHEMBL6431364 0.78 ACHE (0.61) ALDH1A1MAPK1KIF11HSD17B10TDP1
Biphenyl SCHEMBL22288245 0.77 ALDH1A1 (0.56) ALDH1A1MAPK1SLC22A2SLC22A1SLC22A3
Bromobenzene SCHEMBL29215797 0.76 ALDH1A1 (0.58) ALDH1A1MAPK1SLC6A4HSD17B10TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110256422-A A kind of synthetic method of mannosidase inhibitor Kifunensine 天津国际生物医药联合研究院 2019-09-20 CN claimed
CN-107619845-A A kind of preparation method of collagen 吴义峰 2018-01-23 CN claimed
CN-102898487-B A kind of sulphur reaches liver certain herbaceous plants with big flowers sodium disaccharides intermediate fragments BA and synthetic method thereof Mai Keluofu (Nantong) Biology Pharmacy Co., Ltd (CN) 2016-03-09 CN claimed
CN-104860831-A 4-hydroxy ephedrine hydrochloride synthesis method LI YUSHAN 2015-08-26 CN claimed
CN-103288698-A Novel method for synthetizing prostaglandin analogue BEIJING LOUSTON FINE CHEMICAL CO LTD 2013-09-11 CN claimed
CN-102898487-A Fondaparinux sodium disaccharide intermediate fragment BA and synthetic method thereof MCCULL PHARMA NANTONG INC 2013-01-30 CN claimed
CN-101812060-B Simple novel method for preparing high-purity Sprycel, and intermediate compound NANJING CAVENDISH BIOENGINEERING TECHNOLOGY CO LTD 2011-08-17 CN claimed
CN-100503608-C Deazapurines and their use EISAI CO LTD (JP) 2009-06-24 CN claimed
CN-115636776-A With PGF 2α Method for synthesizing alprostadil by using by-product in synthesis as raw material 厦门欧瑞捷生物科技有限公司 2023-01-24 CN disclosed
CN-112079679-B Asymmetric total synthesis method of sex pheromone (R, Z) -21-methyl-8-thirty-five carbene of longicorn 塔里木大学 2022-10-11 CN disclosed
CN-112079679-A Asymmetric total synthesis method of sex pheromone (R, Z) -21-methyl-8-thirty-five carbene of longicorn 塔里木大学 2020-12-15 CN disclosed
CN-110437292-A A kind of preparation method for the thymidine that 2 '-O- replace HONGENE BIOTECHNOLOGY LTD 2019-11-12 CN disclosed
CN-110407900-A A kind of preparation method for the uridine that 2 '-O- replace HONGENE BIOTECHNOLOGY LTD 2019-11-05 CN disclosed
CN-110372571-A A kind of 2- (2,2- diaryl ethyl)-Cycloamine derivative or salt and synthesis and application and composition 中国科学院大连化学物理研究所 2019-10-25 CN disclosed
CN-1130362-C Nucleoside analogues, these compounds as antiviral agents comprising inhibitors of the reverse transcriptase and DNA polymerase of retroviruses of Hepatitis B Virus (HBV) MEDIVIR AB (SE) 2003-12-10 CN disclosed
CN-1275983-A Nucleoside analogues, these compounds as antiviral agents comprising inhibitors of the reverse transcriptase and DNA polymerase of retroviruses of Hepatitis B Virus (HBV) MEDIVIR AB (SE) 2000-12-06 CN disclosed
CN-1045207-C Farnesyl: protein transferase inhibitors as anticancer agents MERRELL DOW PARMACEUTICAL INC (US) 1999-09-22 CN disclosed
CN-1213305-A Novel cycloalkyl substituted imidazolium compounds SMITHKLINE BEECHAM CORP (US) 1999-04-07 CN disclosed
CN-1192147-A Imidazole compounds SMITHKLINE BEECHAM CORP (US) 1998-09-02 CN disclosed
CN-1118166-A Farnesyl: protein transferase inhibitors as anti-cancer agents MERRELL DOW PHARMA (US) 1996-03-06 CN disclosed