Biphenyl

Biphenyl

SCHEMBL2304558

CC(C)(C)O[SiH3].c1ccc(-c2ccccc2)cc1

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.50
MAPK1 P28482 2/20 0.40
SLC22A2 O15244 1/20 0.40
SLC22A1 O15245 1/20 0.40
SLC22A3 O75751 1/20 0.40
SLC6A4 P31645 1/20 0.40
KIF11 P52732 1/20 0.39
CYP1A2 P05177 2/20 0.38
HSD17B10 Q99714 2/20 0.38
TDP1 Q9NUW8 2/20 0.38
TAAR1 Q96RJ0 2/20 0.38
CYP3A4 P08684 1/20 0.38
NOTUM Q6P988 1/20 0.38
MMP3 P08254 1/20 0.38
BCL2L1 Q07817 1/20 0.38
ALOX15 P16050 1/20 0.37
MAPT P10636 2/20 0.36
CYP1A1 P04798 1/20 0.36
CYP1B1 Q16678 1/20 0.36
AKT1 P31749 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Biphenyl SCHEMBL1193167 0.80 ALDH1A1 (0.53) ALDH1A1MAPK1SLC22A2SLC22A1SLC22A3
Biphenyl SCHEMBL28173511 0.80 ALDH1A1 (0.53) ALDH1A1MAPK1SLC22A2SLC22A1SLC22A3
Biphenyl SCHEMBL7639292 0.79 ALDH1A1 (0.60) ALDH1A1MAPK1SLC22A2SLC22A1SLC22A3
Biphenyl SCHEMBL27692765 0.79 ALDH1A1 (0.60) ALDH1A1MAPK1SLC22A2SLC22A1SLC22A3
Aniline SCHEMBL28480918 0.79 TSHR (0.55) ALDH1A1MAPK1CYP1A2HSD17B10TDP1
Biphenyl SCHEMBL6116263 0.78 ALDH1A1 (0.69) ALDH1A1MAPK1SLC22A2SLC22A1SLC22A3
Biphenyl SCHEMBL9483986 0.78 ALDH1A1 (0.69) ALDH1A1MAPK1SLC22A2SLC22A1SLC22A3
Biphenyl SCHEMBL27745920 0.78 ALDH1A1 (0.69) ALDH1A1MAPK1SLC22A2SLC22A1SLC22A3
Biphenyl SCHEMBL21467263 0.78 ALDH1A1 (0.50) ALDH1A1MAPK1SLC22A2SLC22A1SLC22A3
SCHEMBL21496103 0.77 TSHR (0.67) ALDH1A1MAPK1KIF11CYP1A2HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120022242-A Multifunctional nano preparation for reversing tumor immunity microenvironment and preparation method and application thereof 浙江大学长三角智慧绿洲创新中心 2025-05-23 CN claimed
CN-119285689-A Galactoside antitumor prodrug intermediate, and preparation and application thereof 江南大学 2025-01-10 CN claimed
CN-116375779-B Method for stereoselective synthesis of 2' -deoxyribonucleoside 中国药科大学 2024-12-31 CN claimed
CN-111205296-B Oxycodone compound and intermediate and preparation method thereof 中国科学院上海有机化学研究所 2022-10-04 CN claimed
CN-110713533-B 25-hydroxy vitamin D3Antigen and method for producing the same 杭州隆基生物技术有限公司 2021-03-16 CN claimed
WO-2021027614-A1 MODIFIED NUCLEOSIDE AND SYNTHESIS METHOD THEREFOR 斯微(上海)生物科技有限公司 2021-02-18 WO claimed
CN-111205296-A Oxycodone compound and intermediate and preparation method thereof 中国科学院上海有机化学研究所 2020-05-29 CN claimed
CN-110713533-A 25-hydroxy vitamin D3Antigen and method for producing the same 杭州隆基生物技术有限公司 2020-01-21 CN claimed
US-20030069414-A1 Urea nucleosides as therapeutic and diagnostic agents GILEAD SCIENCES, INC. 2003-04-10 US claimed
US-6143882-A REACTING A NUCLEOSIDE STARTING MATERIAL CONTAINING A LEAVING GROUP WITH A VINYLSTANNE OF DEFINED FORMULA AND CARBON MONOXIDE IN PRESENCE OF A PALLADIUM CATALYST TO FORM AN ENE-ONE INTERMEDIATE, REACTING WITH AN AMINE, AND ISOLATING NEXSTAR PHARMACEUTICALS, INC. (US) 2000-11-07 US claimed
WO-1997035868-A9 UREA NUCLEOSIDES AS THERAPEUTIC AND DIAGNOSTIC AGENTS 1997-12-24 WO claimed
WO-1997035868-A1 UREA NUCLEOSIDES AS THERAPEUTIC AND DIAGNOSTIC AGENTS NEXSTAR PHARMACEUTICALS, INC. (US) 1997-10-02 WO claimed
US-12545931-B2 Method for transfection into cardiomyocytes using cationic lipid TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2026-02-10 US disclosed
US-12479791-B2 Cationic lipid TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2025-11-25 US disclosed
US-20250197343-A1 CATIONIC LIPID TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2025-06-19 US disclosed
CN-115745884-B Opioid derivatives, intermediates and process for preparing the same 绍兴赜军生物医药科技有限公司 2025-06-13 CN disclosed
CN-1964713-A Co-use of dopamine-receptor binding compounds DARPHARMA INC (US) 2007-05-16 CN disclosed
CN-1886421-A Hemiasterlin derivatives and uses thereof EISAI CO LTD (JP) 2006-12-27 CN disclosed
US-6150373-A AMINO-SUBSTITUTED DIHYDROPYRIMIDO(4,5-D)PYRIMIDINONE DERIVATIVES; INHIBITORS OF THE T-CELL TYROSINE KINASE P56LCK; IMMUNOSUPPRESSANTS; ANTIINFLAMMATORY/-CARCINOGENIC AGENTS; BRONCHOPULMONARY, DERMATOLOGICAL AND CARDIOVASCULAR DISORDERS HOFFMANN-LA ROCHE INC. (US) 2000-11-21 US disclosed
CN-1199338-A Novel fused isoquinolines as dopamine receptor ligands PURDUE RESEARCH FOUNDATION (US) 1998-11-18 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250197343-A1 CATIONIC LIPID NR1H3, NR1H2, NR1H4 ALDH1A1 2469/4885MAPK1 4137/4885SLC22A2 94/4885
US-12479791-B2 Cationic lipid LIPC, NPC1, LPCAT1 ALDH1A1 1918/4885MAPK1 3447/4885SLC22A2 366/4885
US-12545931-B2 Method for transfection into cardiomyocytes using cationic lipid TNNT2, TNNC1, TNNI3 ALDH1A1 4627/4885MAPK1 1957/4885SLC22A2 448/4885
US-20030069414-A1 Urea nucleosides as therapeutic and diagnostic agents NUDT1, ADAR, DUT ALDH1A1 1549/4885MAPK1 2462/4885SLC22A2 3998/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.