Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23094272 | 0.80 | TDP1 (0.77) | TDP1RAB9AMAPTNPC1L3MBTL1 | |
| SCHEMBL21467923 | 0.80 | TDP1 (0.60) | TDP1RAB9AATMMAPTNPC1 | |
| SCHEMBL21467761 | 0.77 | MAPT (0.55) | TDP1RAB9AATMMAPTNPC1 | |
| SCHEMBL21467944 | 0.70 | TDP1 (0.45) | TDP1RAB9AATMMAPTNPC1 | |
| SCHEMBL23094278 | 0.69 | TDP1 (0.72) | TDP1MAPTL3MBTL1SMN1; SMN2RECQL | |
| SCHEMBL584257 | 0.67 | ATM (0.65) | TDP1RAB9AATMMAPTNPC1 | |
| SCHEMBL23094275 | 0.67 | TDP1 (1.00) | TDP1MAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL23094249 | 0.67 | TDP1 (0.75) | TDP1MAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL23094267 | 0.67 | L3MBTL1 (0.47) | TDP1MAPTL3MBTL1HPGDCYP3A4 | |
| SCHEMBL10965240 | 0.65 | ATM (0.58) | TDP1RAB9AATMMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190315681-A1 | SMALL MOLECULE FERROPTOSIS INDUCERS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2019-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190315681-A1 | SMALL MOLECULE FERROPTOSIS INDUCERS | GPX4, AIFM2, GPX1 | TDP1 4664/4885RAB9A 2758/4885ATM 1966/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.