Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.43 |
| ▸ | PPARA | Q07869 | 3/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 8/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23094229 | 0.74 | L3MBTL1 (0.60) | TDP1CYP1A2CYP3A4PPARAABCB11 | |
| SCHEMBL21467924 | 0.70 | TDP1 (0.50) | TDP1CYP1A2CYP3A4MAPTL3MBTL1 | |
| SCHEMBL21467950 | 0.69 | TDP1 (0.49) | TDP1CYP1A2CYP3A4PPARAABCB11 | |
| SCHEMBL21467882 | 0.68 | PPARG (0.43) | TDP1CYP3A4PPARAMAPTL3MBTL1 | |
| SCHEMBL2121452 | 0.68 | PPARA (0.68) | TDP1CYP1A2CYP3A4PPARAABCB11 | |
| SCHEMBL21991758 | 0.68 | PPARA (0.49) | TDP1CYP1A2CYP3A4PPARAABCB11 | |
| SCHEMBL4914396 | 0.66 | RAB9A (0.58) | TDP1IDO1CYP1A2CYP3A4MAPT | |
| Propionic Acid SCHEMBL27835649 | 0.65 | PPARA (0.59) | TDP1CYP1A2CYP3A4PPARAABCB11 | |
| SCHEMBL11684008 | 0.65 | PPARA (0.62) | TDP1CYP1A2CYP3A4PPARAABCB11 | |
| SCHEMBL21991231 | 0.65 | PPARA (0.62) | TDP1CYP1A2CYP3A4PPARAABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190315681-A1 | SMALL MOLECULE FERROPTOSIS INDUCERS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2019-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190315681-A1 | SMALL MOLECULE FERROPTOSIS INDUCERS | GPX4, AIFM2, GPX1 | TDP1 4664/4885IDO1 3655/4885CYP1A2 3013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.