Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 3/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.43 |
| ▸ | PRNP | P04156 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29791251 | 0.74 | ADRA2A (0.47) | ADRA2AADRA2BADRA2CPRNPRXFP1 | |
| SCHEMBL9403398 | 0.74 | PRNP (0.46) | ADRA2AADRA2BADRA2CPRNPRXFP1 | |
| SCHEMBL30849365 | 0.74 | ADRA2A (0.43) | ADRA2AADRA2BADRA2CPRNPRXFP1 | |
| SCHEMBL10321155 | 0.74 | ADRA2A (0.43) | ADRA2AADRA2BADRA2CPRNPRXFP1 | |
| SCHEMBL11961587 | 0.74 | ADRA2A (0.47) | ADRA2AADRA2BADRA2CPRNPRXFP1 | |
| SCHEMBL23193964 | 0.74 | ADRA2A (0.43) | ADRA2AADRA2BADRA2CPRNPRXFP1 | |
| SCHEMBL5464319 | 0.74 | ADRA2A (0.47) | ADRA2AADRA2BADRA2CPRNPRXFP1 | |
| SCHEMBL20614676 | 0.72 | — | — | |
| SCHEMBL25834805 | 0.72 | PNMT (0.50) | ADRA2AADRA2BADRA2CSMN1; SMN2 | |
| SCHEMBL5120809 | 0.70 | ADRA2A (0.47) | ADRA2AADRA2BADRA2CPRNPRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021252644-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF | Pardes Biosciences, Inc. (US) | 2021-12-16 | — | — | WO | disclosed |
| WO-2019199908-A1 | HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS | ENANTA PHARMACEUTICALS, INC. (US) | 2019-10-17 | — | — | WO | disclosed |