SCHEMBL9403398

SCHEMBL9403398

Brc1cnc2c(c1)CCC2

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRNP P04156 1/20 0.46
RXFP1 Q9HBX9 1/20 0.46
ADRA2A P08913 3/20 0.43
ADRA2B P18089 3/20 0.43
ADRA2C P18825 3/20 0.43
HTT P42858 1/20 0.35
KMT2A Q03164 1/20 0.35
SPR P35270 1/20 0.34
ABHD6 Q9BV23 1/20 0.34
GAA P10253 1/20 0.33
NOS3 P29474 1/20 0.33
NOS1 P29475 1/20 0.33
NOS2 P35228 1/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
LMNA P02545 1/20 0.33
MAPT P10636 1/20 0.33
NR2F2 P24468 1/20 0.33
RAB9A P51151 1/20 0.33
ATM Q13315 1/20 0.33
NPC1 O15118 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5120809 0.96 ADRA2A (0.47) PRNPRXFP1ADRA2AADRA2BADRA2C
SCHEMBL10321155 0.74 ADRA2A (0.43) PRNPRXFP1ADRA2AADRA2BADRA2C
SCHEMBL29791251 0.74 ADRA2A (0.47) PRNPRXFP1ADRA2AADRA2BADRA2C
SCHEMBL5464319 0.74 ADRA2A (0.47) PRNPRXFP1ADRA2AADRA2BADRA2C
SCHEMBL20406311 0.74 ADRA2A (0.47) PRNPRXFP1ADRA2AADRA2BADRA2C
SCHEMBL23193964 0.74 ADRA2A (0.43) PRNPRXFP1ADRA2AADRA2BADRA2C
SCHEMBL30849365 0.74 ADRA2A (0.43) PRNPRXFP1ADRA2AADRA2BADRA2C
SCHEMBL11961587 0.74 ADRA2A (0.47) PRNPRXFP1ADRA2AADRA2BADRA2C
SCHEMBL21471997 0.74 ADRA2A (0.43) PRNPRXFP1ADRA2AADRA2BADRA2C
SCHEMBL4201272 0.74 ABHD6 (0.35) HTTKMT2AABHD6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260028348-A1 MODULATORS OF TNF-ALPHA ACTIVITY FORWARD THERAPEUTICS INC (US) 2026-01-29 US disclosed
US-12509431-B2 1,4-dihydroquinazolinone compounds and uses thereof EDGEWISE THERAPEUTICS, INC. (US) 2025-12-30 US disclosed
US-20250361213-A1 1,4-DIHYDROQUINAZOLINONE COMPOUNDS AND USES THEREOF EDGEWISE THERAPEUTICS INC (US) 2025-11-27 US disclosed
US-12410179-B2 Modulators of TNF alpha activity and uses thereof RAYTHERA, INC. (US) 2025-09-09 US disclosed
US-20250263418-A1 MODULATORS OF TNF ALPHA ACTIVITY AND USES THEREOF RAYTHERA, INC. 2025-08-21 US disclosed
EP-4594307-A1 1,4-DIHYDROQUINAZOLINONE COMPOUNDS AND USES THEREOF EDGEWISE THERAPEUTICS, INC. (US) 2025-08-06 EP disclosed
US-20250154111-A1 1,4-DIHYDROQUINAZOLINONE COMPOUNDS AND USES THEREOF EDGEWISE THERAPEUTICS, INC. 2025-05-15 US disclosed
CN-119630670-A Modulators of TNFalpha activity and uses thereof 瑞雷拉公司 2025-03-14 CN disclosed
US-20250066375-A1 MODULATORS OF TNF ALPHA ACTIVITY AND USES THEREOF RAYTHERA, INC. 2025-02-27 US disclosed
WO-2025038927-A1 MODULATORS OF TNF ALPHA ACTIVITY AND USES THEREOF RAYTHERA, INC. (US) 2025-02-20 WO disclosed
US-20160200736-A1 NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) 2016-07-14 US disclosed
EP-3010914-A1 INDOLIN-2-ONE OR PYRROLO-PYRIDIN/PYRIMIDIN-2-ONE DERIVATIVES F. Hoffmann-La Roche AG (CH) 2016-04-27 EP disclosed
US-20160095844-A1 INDOLIN-2-ONE OR PYRROLO-PYRIDIN/PYRIMIDIN-2-ONE DERIVATIVES HOFFMANN-LA ROCHE INC. (US) 2016-04-07 US disclosed
US-20150252011-A1 PERFLUORINATED CYCLOPROPYL FUSED 1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE AMGEN INC (US) 2015-09-10 US disclosed
WO-2015125085-A1 COMPOUNDS FOR USE AS GPR120 AGONISTS Piramal Enterprises Limited (IN) 2015-08-27 WO disclosed
US-9085576-B2 Perfluorinated cyclopropyl fused 1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use AMGEN INC. (US) 2015-07-21 US disclosed
WO-2015084692-A1 ANTIDIABETIC BICYCLIC COMPOUNDS MERCK SHARP & DOHME CORP. (US) 2015-06-11 WO disclosed
WO-2014202493-A1 INDOLIN-2-ONE OR PYRROLO-PYRIDIN/PYRIMIDIN-2-ONE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2014-12-24 WO disclosed
US-20140275058-A1 PERFLUORINATED CYCLOPROPYL FUSED 1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE AMGEN INC. 2014-09-18 US disclosed
US-5338740-A Angiotensin II receptor antagonists PFIZER INC. (US) 1994-08-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160200736-A1 NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS DGAT1, DGAT2, LCAT PRNP 4768/4885RXFP1 4446/4885ADRA2A 2585/4885
US-20250066375-A1 MODULATORS OF TNF ALPHA ACTIVITY AND USES THEREOF TNF, TNFRSF1A, TNFRSF9 PRNP 936/4885RXFP1 3276/4885ADRA2A 659/4885
US-12410179-B2 Modulators of TNF alpha activity and uses thereof TNF, TNFRSF1A, TNFRSF9 PRNP 936/4885RXFP1 3276/4885ADRA2A 659/4885
US-12509431-B2 1,4-dihydroquinazolinone compounds and uses thereof TNNT2, TNNI3, TNNC1 PRNP 4076/4885RXFP1 160/4885ADRA2A 219/4885
US-20140275058-A1 PERFLUORINATED CYCLOPROPYL FUSED 1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE BACE1, BACE2, APP PRNP 286/4885RXFP1 762/4885ADRA2A 203/4885
US-20250154111-A1 1,4-DIHYDROQUINAZOLINONE COMPOUNDS AND USES THEREOF TNNI3, TNNT2, SDHA PRNP 4084/4885RXFP1 985/4885ADRA2A 624/4885
US-20250361213-A1 1,4-DIHYDROQUINAZOLINONE COMPOUNDS AND USES THEREOF TNNI3, TNNT2, SDHA PRNP 4084/4885RXFP1 985/4885ADRA2A 624/4885
US-20250263418-A1 MODULATORS OF TNF ALPHA ACTIVITY AND USES THEREOF TNF, TNFRSF1A, TNFRSF9 PRNP 936/4885RXFP1 3276/4885ADRA2A 659/4885
US-20160095844-A1 INDOLIN-2-ONE OR PYRROLO-PYRIDIN/PYRIMIDIN-2-ONE DERIVATIVES HTR2C, OPRD1, DRD3 PRNP 1201/4885RXFP1 1350/4885ADRA2A 246/4885
US-20260028348-A1 MODULATORS OF TNF-ALPHA ACTIVITY TNF, TNFRSF1A, TNFRSF9 PRNP 1581/4885RXFP1 511/4885ADRA2A 1371/4885
US-20150252011-A1 PERFLUORINATED CYCLOPROPYL FUSED 1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE BACE1, BACE2, APP PRNP 286/4885RXFP1 762/4885ADRA2A 203/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.