Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.66 |
| ▸ | AKT1 | P31749 | 8/20 | 0.66 |
| ▸ | MTOR | P42345 | 8/20 | 0.66 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.63 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL21465351 | 0.92 | PIK3CA (0.57) | PIK3CAAKT1MTORPIK3C3 | |
| SCHEMBL23438586 | 0.85 | PIK3CA (0.72) | PIK3CAAKT1MTOR | |
| SCHEMBL21465344 | 0.82 | PIK3CA (0.67) | PIK3CAAKT1MTORPIK3C3PKM | |
| SCHEMBL21464307 | 0.79 | PIK3CA (1.00) | PIK3CAAKT1MTOR | |
| SCHEMBL21465348 | 0.78 | PIK3CA (0.59) | PIK3CAAKT1MTORPIK3C3PKM | |
| SCHEMBL7316756 | 0.75 | KDM4E (0.51) | — | |
| SCHEMBL29922811 | 0.73 | PIK3CA (1.00) | PIK3CAAKT1MTOR | |
| SCHEMBL23407475 | 0.73 | PIK3CA (1.00) | PIK3CAAKT1MTOR | |
| SCHEMBL21464158 | 0.73 | PKM (0.68) | PIK3CAAKT1MTORPKMTSHR | |
| SCHEMBL21469757 | 0.72 | PIK3CA (1.00) | PIK3CAAKT1MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3774792-B1 | MORPHOLINE DERIVATES AS INHIBITORS OF VPS34 | NEUROPORE THERAPIES INC (US) | 2022-09-14 | — | — | EP | disclosed |
| US-11236079-B2 | Morpholine derivates as inhibitors of Vps34 | NEUROPORE THERAPIES, INC. (US) | 2022-02-01 | — | — | US | disclosed |
| US-11236079-B2 | Morpholine derivates as inhibitors of Vps34 | NEUROPORE THERAPIES, INC. (US) | 2022-02-01 | — | — | US | disclosed |
| US-20210163467-A1 | MORPHOLINE DERIVATES AS INHIBITORS OF VPS34 | NEUROPORE THERAPIES, INC. (US) | 2021-06-03 | — | — | US | disclosed |
| US-20210163467-A1 | MORPHOLINE DERIVATES AS INHIBITORS OF VPS34 | NEUROPORE THERAPIES, INC. (US) | 2021-06-03 | — | — | US | disclosed |
| WO-2019199874-A1 | MORPHOLINE DERIVATES AS INHIBITORS OF VPS34 | NEUROPORE THERAPIES, INC. (US) | 2019-10-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11236079-B2 | Morpholine derivates as inhibitors of Vps34 | VPS35, TFEB, VPS4B | PIK3CA 114/4885AKT1 155/4885MTOR 52/4885 |
| US-20210163467-A1 | MORPHOLINE DERIVATES AS INHIBITORS OF VPS34 | VPS35, TFEB, VPS4B | PIK3CA 114/4885AKT1 155/4885MTOR 52/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.