SCHEMBL21475705

SCHEMBL21475705

COc1ccc(C(OC2C(O)C(n3ccc(=O)[nH]c3=O)OC2C(C)O)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.43

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
P2RY14 Q15391 3/20 0.43
SLC28A1 O00337 1/20 0.39
SLC28A2 O43868 1/20 0.39
SLC29A1 Q99808 1/20 0.39
SLC28A3 Q9HAS3 1/20 0.39
TYMP P19971 1/20 0.39
P2RY2 P41231 6/20 0.39
P2RY6 Q15077 5/20 0.39
P2RY4 P51582 3/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL781934 0.91 P2RY14 (0.38) P2RY14SLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL780531 0.91 P2RY14 (0.38) P2RY14SLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL800758 0.90 P2RY14 (0.38) P2RY14SLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL800304 0.90 P2RY14 (0.38) P2RY14SLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL21461830 0.89 P2RY14 (0.41) P2RY14SLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL21475704 0.86 P2RY14 (0.40) P2RY14SLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL8390570 0.85 SLC28A1 (0.54) P2RY14SLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL4387787 0.83 TYMP (0.53) P2RY14SLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL13589363 0.83 TYMP (0.53) P2RY14SLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL8970268 0.83 P2RY14 (0.46) P2RY14SLC28A1SLC28A2SLC29A1SLC28A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10927140-B2 Compositions and methods for reverse automated nucleic acid synthesis THE UNIVERSITY OF TOLEDO (US) 2021-02-23 US disclosed
US-20190315794-A1 Compositions and Methods for Reverse Automated Nucleic Acid Synthesis THE UNIVERSITY OF TOLEDO (US) 2019-10-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190315794-A1 Compositions and Methods for Reverse Automated Nucleic Acid Synthesis RNGTT, POLRMT, POLN P2RY14 3406/4885SLC28A1 1608/4885SLC28A2 1710/4885
US-10927140-B2 Compositions and methods for reverse automated nucleic acid synthesis RNGTT, POLRMT, POLN P2RY14 3406/4885SLC28A1 1608/4885SLC28A2 1710/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.