⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23660466 | 0.91 | CA1 (0.33) | — | |
| SCHEMBL20334521 | 0.87 | LGALS8 (0.33) | — | |
| SCHEMBL12292292 | 0.87 | LGALS8 (0.33) | — | |
| SCHEMBL19661469 | 0.87 | LGALS8 (0.33) | — | |
| SCHEMBL16729887 | 0.82 | LGALS8 (0.30) | — | |
| SCHEMBL18390208 | 0.82 | LGALS8 (0.30) | — | |
| SCHEMBL20966340 | 0.81 | LGALS8 (0.41) | — | |
| SCHEMBL21374841 | 0.81 | LGALS8 (0.41) | — | |
| SCHEMBL13706079 | 0.80 | TLR4 (0.31) | — | |
| SCHEMBL26029385 | 0.80 | TLR4 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11549107-B2 | Compositions and methods for treating alpha-1 antitrypsin deficiency | INTELLIA THERAPEUTICS, INC. (US) | 2023-01-10 | — | — | US | disclosed |
| US-20190316129-A1 | Compositions and Methods for Treating Alpha-1 Antitrypsin Deficiency | INTELLIA THERAPEUTICS, INC. (US) | 2019-10-17 | — | — | US | disclosed |