Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 2/20 | 0.40 |
| ▸ | BRAF | P15056 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15072164 | 0.93 | KMT2A (0.50) | ALDH1A1KMT2ASMN1; SMN2HPGDKDM4E | |
| SCHEMBL218118 | 0.88 | KMT2A (0.57) | ALDH1A1KMT2ASMN1; SMN2HPGDKDM4E | |
| Ammonia Solution, Strong SCHEMBL10418488 | 0.86 | KMT2A (0.55) | ALDH1A1KMT2ASMN1; SMN2HPGDKDM4E | |
| SCHEMBL7048807 | 0.82 | SCN4A (0.51) | ALDH1A1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL15941989 | 0.82 | FLT3 (0.59) | ALDH1A1SMN1; SMN2KDM4EDYRK1ANOTUM | |
| Formamide SCHEMBL29227819 | 0.82 | HTT (0.48) | ALDH1A1KMT2ASMN1; SMN2HPGDKDM4E | |
| SCHEMBL6677484 | 0.81 | ALDH1A1 (0.50) | ALDH1A1KMT2AKDM4EL3MBTL1HTT | |
| SCHEMBL13679138 | 0.80 | HTT (0.65) | ALDH1A1KMT2ASMN1; SMN2HPGDKDM4E | |
| SCHEMBL27260683 | 0.80 | POLB (0.48) | ALDH1A1KMT2ASMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL554497 | 0.80 | KMT2A (0.55) | KMT2ASMN1; SMN2KDM4EHSD17B10L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130040983-A1 | RAF KINASE INHIBITORS | RUGA CORPORATION | 2013-02-14 | — | — | US | disclosed |
| WO-2011085269-A1 | RAF KINASE INHIBITORS | SELEXAGEN THERAPEUTICS, INC. (US) | 2011-07-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130040983-A1 | RAF KINASE INHIBITORS | BRAF, RAF1, ARAF | ALDH1A1 2793/4885KMT2A 1823/4885SMN1; SMN2 3112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.