SCHEMBL2148581

SCHEMBL2148581

COc1cnc(O)nc1O

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.38
KMT2A Q03164 1/20 0.35
PDGFRB P09619 2/20 0.35
PDGFRA P16234 2/20 0.35
NQO2 P16083 1/20 0.34
TP53 P04637 2/20 0.33
CYP3A4 P08684 2/20 0.33
MAPT P10636 2/20 0.33
KDM4E B2RXH2 2/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
TSHR P16473 1/20 0.33
SMPD3 Q9NY59 1/20 0.33
NUDT1 P36639 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
IDO1 P14902 2/20 0.33
TDO2 P48775 2/20 0.33
LMNA P02545 1/20 0.32
HPGD P15428 1/20 0.32
ALOX15 P16050 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31366357 1.00 ALDH1A1 (0.38) ALDH1A1KMT2APDGFRBPDGFRANQO2
SCHEMBL9045721 0.80 P2RX3 (0.37) ALDH1A1KMT2APDGFRBPDGFRANQO2
SCHEMBL3166513 0.80 KMT2A (0.50) ALDH1A1KMT2APDGFRBPDGFRATP53
SCHEMBL3169433 0.80 FTO (0.40) ALDH1A1KMT2APDGFRBPDGFRANQO2
SCHEMBL12062617 0.80 KDM4E (0.40) ALDH1A1KMT2APDGFRBPDGFRATP53
SCHEMBL15180943 0.78 ALDH1A1 (0.52) ALDH1A1KMT2APDGFRBPDGFRANQO2
SCHEMBL12986327 0.78 NUDT1 (0.49) MAPTTSHRNUDT1JAK2JAK1
SCHEMBL2148346 0.78 AOC3 (0.38) ALDH1A1KMT2ACYP3A4MAPTKDM4E
SCHEMBL18156588 0.78 ALDH1A1 (0.35) ALDH1A1KMT2APDGFRBPDGFRANQO2
SCHEMBL20631602 0.77 MEN1 (0.33) ALDH1A1KMT2AKDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110240601-A Synthesis method of penoxsulam intermediate 湖北广富林生物制剂有限公司 2019-09-17 CN claimed
CN-106243045-A A kind of preparation method of 2,5 dimethoxy 4 aminopyrimidines 常州大学 2016-12-21 CN claimed
CN-104326988-B A kind of synthetic method of 2,4-dichloro-5-methoxy pyrimidines 大连九信生物化工科技有限公司 2016-06-08 CN claimed
CN-105646368-A Preparation method of 2, 4-dichloro-5-methoxy pyrimidine 深圳诺普信农化股份有限公司 2016-06-08 CN claimed
CN-104326988-A Synthesis method for 2, 4-dichloro-5-methoxy pyrimidine DALIAN JOIN KING BIOCHEM TECH CO LTD 2015-02-04 CN claimed
CN-102060782-A Method for preparing chloropyrimidines or analogues thereof ZHIHUA SUN 2011-05-18 CN claimed
CN-101486684-B Preparation of 2,4-dichloro-5-methoxy pyrimidine CHANGZHOU HUAYI CHEMICAL CO LTD 2010-11-10 CN claimed
CN-101486684-A Preparation of 2,4-dichloro-5-methoxy pyrimidine CHANGZHOU HUAYI CHEMICAL CO LT (CN) 2009-07-22 CN claimed
WO-2024233665-A1 COMPOUNDS AND THEIR USE AGAINST CANCER TANGO THERAPEUTICS, INC. (US) 2024-11-14 WO disclosed
CN-115417875-B Synthesis method of 5, 8-dimethoxy- [1,2,4] triazolo [1,5-C ] pyrimidine-2-amine 山东华升新材料有限公司 2024-05-31 CN disclosed
US-11935803-B2 Resin composition, laminate, semiconductor wafer with resin composition layer, substrate for mounting semiconductor with resin composition layer and semiconductor device MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2024-03-19 US disclosed
CN-115417875-A Synthesis method of 5,8-dimethoxy- [1,2,4] triazolo [1,5-C ] pyrimidine-2-amine 山东华升新材料有限公司 2022-12-02 CN disclosed
CN-112004845-B Resin composition, laminate, semiconductor wafer with resin composition layer, substrate, and semiconductor device 三菱瓦斯化学株式会社 2022-05-31 CN disclosed
US-20210277221-A1 RESIN COMPOSITION, LAMINATE, SEMICONDUCTOR WAFER WITH RESIN COMPOSITION LAYER, SUBSTRATE FOR MOUNTING SEMICONDUCTOR WITH RESIN COMPOSITION LAYER AND SEMICONDUCTOR DEVICE MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2021-09-09 US disclosed
CN-101486684-B Preparation of 2,4-dichloro-5-methoxy pyrimidine CHANGZHOU HUAYI CHEMICAL CO LTD 2010-11-10 CN disclosed
CN-101486684-B Preparation of 2,4-dichloro-5-methoxy pyrimidine CHANGZHOU HUAYI CHEMICAL CO LTD 2010-11-10 CN disclosed
CN-101486684-A Preparation of 2,4-dichloro-5-methoxy pyrimidine CHANGZHOU HUAYI CHEMICAL CO LT (CN) 2009-07-22 CN disclosed
CN-101486684-A Preparation of 2,4-dichloro-5-methoxy pyrimidine CHANGZHOU HUAYI CHEMICAL CO LT (CN) 2009-07-22 CN disclosed
EP-1747222-A1 PYRIMIDINE DERIVATIVES ANTAGONISTS OF VITRONECTIN RECEPTOR Proskelia SAS (FR) 2007-01-31 EP disclosed
WO-2005123734-A1 PYRIMIDINE DERIVATIVES ANTAGONISTS OF VITRONECTIN RECEPTOR PROSKELIA SAS (FR) 2005-12-29 WO disclosed