Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL211422 | 0.93 | TDP1 (0.40) | TDP1ALDH1A1MAPTL3MBTL1MAPK1 | |
| SCHEMBL212048 | 0.90 | POLB (0.35) | TDP1NPC1POLBRAB9A | |
| SCHEMBL211133 | 0.87 | CTSK (0.35) | ALDH1A1MAPK1KDM4ERAB9A | |
| SCHEMBL211083 | 0.87 | CTSK (0.35) | ALDH1A1MAPK1KDM4ERAB9A | |
| SCHEMBL2723900 | 0.86 | TDP1 (0.41) | TDP1ALDH1A1MAPTL3MBTL1MAPK1 | |
| SCHEMBL211648 | 0.85 | ABL1 (0.33) | — | |
| SCHEMBL212239 | 0.83 | CSNK2A2 (0.38) | ALDH1A1MAPTSMN1; SMN2NPC1KDM4E | |
| SCHEMBL210546 | 0.83 | CTSK (0.34) | TDP1ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL211861 | 0.83 | CTSK (0.34) | — | |
| SCHEMBL213235 | 0.83 | GAA (0.35) | NPC1POLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |