Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.32 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL213235 | 0.93 | GAA (0.35) | POLBGAAHCRTR1HCRTR2SCN9A | |
| SCHEMBL214863 | 0.90 | TDP1 (0.41) | POLBRAB9ANPC1TDP1 | |
| SCHEMBL2725787 | 0.87 | POLB (0.35) | POLBGAAHCRTR1HCRTR2SCN9A | |
| SCHEMBL211133 | 0.86 | CTSK (0.35) | RAB9A | |
| SCHEMBL211083 | 0.86 | CTSK (0.35) | RAB9A | |
| SCHEMBL212145 | 0.85 | KIT (0.31) | — | |
| SCHEMBL211648 | 0.84 | ABL1 (0.33) | — | |
| SCHEMBL211422 | 0.83 | TDP1 (0.40) | RAB9ANPC1TDP1 | |
| SCHEMBL212523 | 0.82 | SMN1; SMN2 (0.35) | POLBRAB9ANPC1TDP1 | |
| SCHEMBL211156 | 0.81 | CTSK (0.34) | RAB9ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |