Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | TSHR | P16473 | 4/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.61 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.61 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.50 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 4/20 | 0.48 |
| ▸ | PPARD | Q03181 | 4/20 | 0.48 |
| ▸ | PPARA | Q07869 | 4/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.48 |
| ▸ | TLR2 | O60603 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adipic Acid SCHEMBL105756 | 1.00 | LMNA (0.65) | LMNATSHRNFKB1PMP22SLC22A6 | |
| Octanedioate SCHEMBL9642090 | 0.97 | TSHR (0.67) | LMNATSHRNFKB1PMP22SLC22A6 | |
| Azelaic Acid SCHEMBL4094376 | 0.97 | TSHR (0.67) | LMNATSHRNFKB1PMP22SLC22A6 | |
| Sebacic Acid SCHEMBL6135890 | 0.97 | TSHR (0.67) | LMNATSHRNFKB1PMP22SLC22A6 | |
| Pimelic Acid SCHEMBL30384892 | 0.97 | TSHR (0.67) | LMNATSHRNFKB1PMP22SLC22A6 | |
| Adipic Acid SCHEMBL105192 | 0.94 | LMNA (0.65) | LMNATSHRNFKB1PMP22SLC22A6 | |
| Adipic Acid SCHEMBL105952 | 0.94 | LMNA (0.65) | LMNATSHRNFKB1PMP22SLC22A6 | |
| Adipic Acid SCHEMBL30776749 | 0.94 | LMNA (0.65) | LMNATSHRNFKB1PMP22SLC22A6 | |
| Glutarate SCHEMBL106178 | 0.94 | SLC22A6 (0.65) | LMNATSHRNFKB1PMP22SLC22A6 | |
| Adipic Acid SCHEMBL23780654 | 0.92 | LMNA (0.61) | LMNATSHRNFKB1PMP22SLC22A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11938109-B2 | Methods for the preparation of a levothyroxine solution | EMP LEVO US B.V. (NL) | 2024-03-26 | — | — | US | claimed |
| US-20210353577-A1 | METHODS FOR THE PREPARATION OF A LEVOTHYROXINE SOLUTION | EMP LEVO US B.V. (NL) | 2021-11-18 | — | — | US | claimed |
| US-20190321316-A1 | METHODS FOR THE PREPARATION OF A LEVOTHYROXINE SOLUTION | EMP LEVO US B.V. (NL) | 2019-10-24 | — | — | US | claimed |
| US-11938109-B2 | Methods for the preparation of a levothyroxine solution | EMP LEVO US B.V. (NL) | 2024-03-26 | — | — | US | disclosed |
| US-20210353577-A1 | METHODS FOR THE PREPARATION OF A LEVOTHYROXINE SOLUTION | EMP LEVO US B.V. (NL) | 2021-11-18 | — | — | US | disclosed |
| US-20190321316-A1 | METHODS FOR THE PREPARATION OF A LEVOTHYROXINE SOLUTION | EMP LEVO US B.V. (NL) | 2019-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11938109-B2 | Methods for the preparation of a levothyroxine solution | TPO, TSHR, TRHDE | LMNA 3650/4885TSHR 2/4885NFKB1 2823/4885 |
| US-20190321316-A1 | METHODS FOR THE PREPARATION OF A LEVOTHYROXINE SOLUTION | TPO, TSHR, TRHDE | LMNA 3650/4885TSHR 2/4885NFKB1 2823/4885 |
| US-20210353577-A1 | METHODS FOR THE PREPARATION OF A LEVOTHYROXINE SOLUTION | TPO, TSHR, TRHDE | LMNA 3650/4885TSHR 2/4885NFKB1 2823/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.