Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2313394 | 0.83 | L3MBTL1 (0.54) | L3MBTL1TDP1KMT2AMEN1LMNA | |
| SCHEMBL2834313 | 0.82 | MEN1 (0.43) | L3MBTL1TDP1KMT2AMEN1LMNA | |
| SCHEMBL2010877 | 0.74 | L3MBTL1 (0.48) | L3MBTL1TDP1KMT2AMEN1TSHR | |
| SCHEMBL2312288 | 0.72 | L3MBTL1 (0.51) | L3MBTL1TDP1KMT2AMEN1LMNA | |
| SCHEMBL2834152 | 0.69 | MEN1 (0.42) | L3MBTL1TDP1KMT2AMEN1LMNA | |
| SCHEMBL15969988 | 0.68 | L3MBTL1 (0.83) | L3MBTL1TDP1KMT2AMEN1LMNA | |
| SCHEMBL2154236 | 0.67 | TACR3 (0.48) | KMT2AMEN1LMNATSHRSMN1; SMN2 | |
| SCHEMBL2830092 | 0.66 | HTT (0.42) | L3MBTL1KMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL164622 | 0.64 | L3MBTL1 (0.72) | L3MBTL1KMT2ATSHRSMN1; SMN2NPC1 | |
| SCHEMBL10150603 | 0.64 | CNR1 (0.44) | L3MBTL1TDP1KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2342182-A1 | ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS | H. Lundbeck A/S (DK) | 2011-07-13 | — | — | EP | claimed |