Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2013388 | 0.90 | THRB (0.39) | L3MBTL1TDP1NPC1RAB9AMAPT | |
| SCHEMBL2015522 | 0.88 | BCL2 (0.42) | L3MBTL1TDP1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL10150960 | 0.79 | PDE10A (0.42) | SMN1; SMN2NPC1MAPTMEN1KMT2A | |
| SCHEMBL10150590 | 0.79 | PDE10A (0.42) | POLBMAPTGAAKMT2A | |
| SCHEMBL2149158 | 0.74 | L3MBTL1 (0.51) | L3MBTL1TDP1TSHRSMN1; SMN2HPGD | |
| SCHEMBL10150961 | 0.73 | PPARG (0.40) | MEN1KMT2A | |
| SCHEMBL2313394 | 0.71 | L3MBTL1 (0.54) | L3MBTL1TDP1TSHRSMN1; SMN2HPGD | |
| SCHEMBL13991132 | 0.68 | MEN1 (0.66) | L3MBTL1TDP1SMN1; SMN2POLBKDM4E | |
| SCHEMBL2832854 | 0.67 | LMNA (0.40) | L3MBTL1TSHRPOLBKDM4ERAB9A | |
| SCHEMBL2736553 | 0.66 | NPC1 (0.59) | L3MBTL1SMN1; SMN2POLBKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011072691-A1 | PYRIDONE DERIVATIVES AS NK3 ANTAGONISTS | H. LUNDBECK A/S (DK) | 2011-06-23 | — | — | WO | claimed |
| WO-2011072691-A1 | PYRIDONE DERIVATIVES AS NK3 ANTAGONISTS | H. LUNDBECK A/S (DK) | 2011-06-23 | — | — | WO | disclosed |