Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.31 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.31 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5046239 | 0.77 | KMT2A (0.35) | PLAUS1PR1S1PR3MEN1MAPT | |
| SCHEMBL21494328 | 0.77 | GABRA1 (0.35) | ALDH1A1NPSR1MAPTNPC1RAB9A | |
| SCHEMBL1543624 | 0.76 | PDXK (0.46) | PLAUALDH1A1MEN1MAPTHPGD | |
| SCHEMBL25233643 | 0.76 | ALDH1A1 (0.39) | PLAUS1PR1S1PR3ALDH1A1NPSR1 | |
| SCHEMBL31430877 | 0.74 | KMT2A (0.37) | PLAUALDH1A1NPSR1MEN1MAPT | |
| SCHEMBL856508 | 0.74 | KMT2A (0.37) | PLAUALDH1A1NPSR1MEN1MAPT | |
| SCHEMBL2968350 | 0.73 | GABRA1 (0.36) | PLAUS1PR1S1PR3ALDH1A1NPSR1 | |
| SCHEMBL28046023 | 0.72 | CYP3A4 (0.36) | PLAUALDH1A1NPSR1MEN1MAPT | |
| SCHEMBL31254092 | 0.72 | KCNJ5 (0.32) | PLAU | |
| SCHEMBL15052847 | 0.72 | HTT (0.34) | PLAUMEN1MAPTHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3784671-A1 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRad Therapeutics, Inc. (US) | 2021-03-03 | — | — | EP | disclosed |
| WO-2019201283-A1 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRAD THERAPEUTICS, INC. (US) | 2019-10-24 | — | — | WO | disclosed |