Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.59 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.59 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | TNF | P01375 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21494482 | 1.00 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL2989854 | 1.00 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL21494466 | 0.99 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL23000633 | 0.99 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL21494464 | 0.99 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL2992087 | 0.94 | ALDH1A1 (0.58) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL6693234 | 0.93 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL28323446 | 0.92 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL4671897 | 0.90 | ACHE (0.59) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL2991798 | 0.90 | ACHE (0.59) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11767295-B2 | Isoindole derivative | TIANJIN HEMAY PHARMACEUTICAL CO., LTD. (CN) | 2023-09-26 | — | — | US | disclosed |
| US-20210155590-A1 | ISOINDOLE DERIVATIVE | TIANJIN HEMAY PHARMACEUTICAL CO., LTD. (CN) | 2021-05-27 | — | — | US | disclosed |
| EP-3782983-A1 | ISOINDOLE DERIVATIVE | Tianjin Hemay Pharmaceutical Co., Ltd. (CN) | 2021-02-24 | — | — | EP | disclosed |
| CN-110386893-A | Isoindole derivatives | 天津合美医药科技有限公司 | 2019-10-29 | — | — | CN | disclosed |
| WO-2019201255-A1 | ISOINDOLE DERIVATIVE | 天津合美医药科技有限公司 | 2019-10-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11767295-B2 | Isoindole derivative | COX4I1, ALDH1A2, GDI2 | PDE4A 1740/4885PDE4B 1378/4885PDE4C 2317/4885 |
| US-20210155590-A1 | ISOINDOLE DERIVATIVE | COX4I1, ALDH1A2, GDI2 | PDE4A 1740/4885PDE4B 1378/4885PDE4C 2317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.