Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | PPARD | Q03181 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30644304 | 0.81 | ALDH1A1 (0.69) | ALDH1A1PPARGPPARDPPARAPTGS1 | |
| SCHEMBL557409 | 0.81 | ALDH1A1 (0.69) | ALDH1A1PPARGPPARDPPARAPTGS1 | |
| SCHEMBL2255231 | 0.80 | ATM (0.47) | ALDH1A1SIGMAR1CA2MEN1KMT2A | |
| SCHEMBL16961640 | 0.80 | ALDH1A1 (0.47) | ALDH1A1SIGMAR1CA2MEN1KMT2A | |
| SCHEMBL3343652 | 0.79 | ALDH1A1 (0.67) | ALDH1A1PPARGPPARDPPARAPTGS1 | |
| SCHEMBL27824291 | 0.77 | KDM4E (0.67) | MEN1KMT2ACYP3A4ATMKDM4E | |
| SCHEMBL21807162 | 0.77 | ALDH1A1 (0.47) | ALDH1A1SIGMAR1NPC1CYP3A4TDP1 | |
| SCHEMBL7375826 | 0.77 | PDE4B (0.57) | — | |
| SCHEMBL21494904 | 0.75 | SOS1 (0.36) | — | |
| SCHEMBL17537954 | 0.74 | ALDH1A1 (0.50) | ALDH1A1PPARGPPARDPPARAPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112313229-A | Substituted aminothiazoles as inhibitors of nucleases | 马萨里克大学 | 2021-02-02 | — | — | CN | disclosed |
| WO-2019201865-A1 | SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES | MASARYKOVA UNIVERZITA (CZ) | 2019-10-24 | — | — | WO | disclosed |