SCHEMBL21495049

SCHEMBL21495049

O=C[C@@H](Br)c1cccc(Br)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.47
IDO1 P14902 1/20 0.42
TDO2 P48775 1/20 0.42
HSD11B1 P28845 1/20 0.38
MAPK1 P28482 1/20 0.37
HSD17B3 P37058 1/20 0.36
PARP1 P09874 1/20 0.35
MGAM O43451 1/20 0.35
GAA P10253 1/20 0.35
SI P14410 1/20 0.35
MGAM2 Q2M2H8 1/20 0.35
CYP3A4 P08684 3/20 0.34
CYP2D6 P10635 3/20 0.34
SLC6A2 P23975 3/20 0.34
SLC6A4 P31645 3/20 0.34
SLC6A3 Q01959 3/20 0.34
KCNH2 Q12809 1/20 0.34
MBTD1 Q05BQ5 1/20 0.33
L3MBTL3 Q96JM7 1/20 0.33
CTSA P10619 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL540882 1.00 ALDH1A1 (0.47) ALDH1A1IDO1TDO2HSD11B1MAPK1
SCHEMBL2756356 0.81 ALDH1A1 (0.48) ALDH1A1IDO1TDO2HSD11B1MAPK1
SCHEMBL6692582 0.81 ALDH1A1 (0.48) ALDH1A1IDO1TDO2HSD11B1MAPK1
SCHEMBL4960285 0.78 ACP3 (0.43) ALDH1A1MAPK1PARP1MGAMGAA
SCHEMBL167914 0.78 HDAC4 (0.44) IDO1TDO2MAPK1CYP3A4CYP2D6
SCHEMBL1701121 0.78 ADRB1 (0.43) ALDH1A1GAACYP3A4SLC6A3
SCHEMBL27752015 0.78
SCHEMBL169020 0.78 ACP3 (0.43) ALDH1A1PARP1MGAMGAASI
SCHEMBL4062829 0.78 SLC6A3 (0.33) CYP3A4CYP2D6SLC6A2SLC6A4SLC6A3
SCHEMBL27992416 0.78 ALDH1A1 (0.50) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3856737-A1 HETEROCYCLYL COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE F. Hoffmann-La Roche AG (CH) 2021-08-04 EP disclosed
WO-2020219808-A1 DICARBAMATE INHIBITORS OF NS5A FOR TREATMENT OF HEPATITIS C VIRUS INFECTIONS AND RELATED DISEASES BETA PHARMA, INC. (US) 2020-10-29 WO disclosed
WO-2020064792-A1 HETEROCYCLYL COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE F. HOFFMANN-LA ROCHE AG (CH) 2020-04-02 WO disclosed
WO-2019201865-A1 SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES MASARYKOVA UNIVERZITA (CZ) 2019-10-24 WO disclosed