Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28037815 | 0.84 | ALDH1A1 (0.42) | MEN1KMT2AALDH1A1CYP3A4POLB | |
| SCHEMBL23183322 | 0.83 | EPHX2 (0.39) | MEN1KMT2ACYP3A4CYP2C19LMNA | |
| SCHEMBL17648648 | 0.83 | EPHX2 (0.39) | MEN1KMT2ACYP3A4CYP2C19LMNA | |
| SCHEMBL3696570 | 0.81 | ALDH1A1 (0.44) | ALDH1A1CYP3A4LMNAMAPTKDM4E | |
| SCHEMBL3368929 | 0.78 | ALDH1A1 (0.57) | MEN1KMT2AHTTALDH1A1POLB | |
| SCHEMBL547428 | 0.71 | MEN1 (0.44) | MEN1KMT2AHTTALDH1A1POLB | |
| Bromide SCHEMBL10516381 | 0.70 | MTNR1A (0.36) | ALDH1A1CYP1A2LMNA | |
| SCHEMBL15084239 | 0.70 | ALDH1A1 (0.41) | MEN1KMT2AALDH1A1CYP3A4CYP2C19 | |
| SCHEMBL3542185 | 0.69 | ALDH1A1 (0.43) | MEN1KMT2AALDH1A1CYP3A4CYP2C19 | |
| SCHEMBL1471124 | 0.69 | PIN1 (0.53) | MEN1KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3784654-A1 | ISOINDOLINES AS HDAC INHIBITORS | Valo Early Discovery, Inc. (US) | 2021-03-03 | — | — | EP | disclosed |
| WO-2019204550-A1 | ISOINDOLINES AS HDAC INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2019-10-24 | — | — | WO | disclosed |