Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 5/20 | 0.44 |
| ▸ | BCR | P11274 | 5/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | CTSC | P53634 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.41 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.40 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.40 |
| ▸ | ACP1 | P24666 | 1/20 | 0.40 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.40 |
| ▸ | SMO | Q99835 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21515892 | 0.86 | CTSC (0.48) | TRPV1ABL1BCRALOX5CTSC | |
| SCHEMBL21497143 | 0.80 | CTSC (0.48) | ABL1BCRCTSCMAPTDHODH | |
| SCHEMBL21497157 | 0.73 | DHODH (0.59) | ABL1BCRCTSCMAPTDHODH | |
| SCHEMBL21499943 | 0.70 | EPHX2 (0.49) | ABL1BCRALOX5CTSCMAPT | |
| SCHEMBL1416502 | 0.70 | KIF11 (0.51) | TRPV1MAPTSCN10A | |
| SCHEMBL10989192 | 0.68 | TRPV1 (0.54) | TRPV1 | |
| SCHEMBL21497177 | 0.68 | EPHX2 (0.48) | ABL1BCRDHODH | |
| SCHEMBL21499858 | 0.68 | EPHX2 (0.52) | ABL1BCRCTSCMAPTDHODH | |
| SCHEMBL22543353 | 0.68 | DHODH (0.62) | ABL1BCRCTSCMAPTDHODH | |
| SCHEMBL1921523 | 0.67 | KIF11 (0.61) | ABL1BCRALOX5MAPTCHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210253538-A1 | AMINOPYRAZINES AND RELATED COMPOUNDS USEFUL AS MITOCHONDRIAL UNCOUPLERS | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. | 2021-08-19 | — | — | US | claimed |
| EP-3781165-A1 | AMINOPYRAZINES AND RELATED COMPOUNDS USEFUL AS MITOCHONDRIAL UNCOUPLERS | Virginia Tech Intellectual Properties, Inc. (US) | 2021-02-24 | — | — | EP | claimed |
| CN-112261941-A | Aminopyrazines and related compounds useful as mitochondrial uncouplers | 弗吉尼亚理工大学知识产权有限公司 | 2021-01-22 | — | — | CN | claimed |
| WO-2019204819-A1 | AMINOPYRAZINES AND RELATED COMPOUNDS USEFUL AS MITOCHONDRIAL UNCOUPLERS | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 2019-10-24 | — | — | WO | claimed |
| US-20210253538-A1 | AMINOPYRAZINES AND RELATED COMPOUNDS USEFUL AS MITOCHONDRIAL UNCOUPLERS | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. | 2021-08-19 | — | — | US | disclosed |
| US-20210253538-A1 | AMINOPYRAZINES AND RELATED COMPOUNDS USEFUL AS MITOCHONDRIAL UNCOUPLERS | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. | 2021-08-19 | — | — | US | disclosed |
| EP-3781165-A1 | AMINOPYRAZINES AND RELATED COMPOUNDS USEFUL AS MITOCHONDRIAL UNCOUPLERS | Virginia Tech Intellectual Properties, Inc. (US) | 2021-02-24 | — | — | EP | disclosed |
| WO-2019204819-A1 | AMINOPYRAZINES AND RELATED COMPOUNDS USEFUL AS MITOCHONDRIAL UNCOUPLERS | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 2019-10-24 | — | — | WO | disclosed |
| WO-2019204819-A1 | AMINOPYRAZINES AND RELATED COMPOUNDS USEFUL AS MITOCHONDRIAL UNCOUPLERS | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 2019-10-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210253538-A1 | AMINOPYRAZINES AND RELATED COMPOUNDS USEFUL AS MITOCHONDRIAL UNCOUPLERS | GLS2, NDUFAF1, NDUFAB1 | TRPV1 1102/4885ABL1 2636/4885BCR 1478/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.