Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGMT | P16455 | 4/20 | 0.50 |
| ▸ | CDK1 | P06493 | 2/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.50 |
| ▸ | CDK2 | P24941 | 2/20 | 0.50 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | MPO | P05164 | 2/20 | 0.48 |
| ▸ | TPO | P07202 | 1/20 | 0.48 |
| ▸ | EPX | P11678 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | ATP4A | P20648 | 1/20 | 0.45 |
| ▸ | ATP4B | P51164 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL557629 | 0.77 | MGMT (0.50) | MGMTCDK1CCNB1CCNA2CDK2 | |
| SCHEMBL29364376 | 0.77 | MGMT (0.50) | MGMTCDK1CCNB1CCNA2CDK2 | |
| SCHEMBL25345378 | 0.77 | MGMT (0.50) | MGMTCDK1CCNB1CCNA2CDK2 | |
| SCHEMBL6358672 | 0.77 | MGMT (0.66) | MGMTCDK1CCNB1CCNA2CDK2 | |
| SCHEMBL17597368 | 0.74 | MGMT (0.46) | MGMTCDK1CCNB1CCNA2CDK2 | |
| SCHEMBL24215176 | 0.72 | L3MBTL1 (0.47) | MGMTCDK1CCNB1CCNA2CDK2 | |
| SCHEMBL669089 | 0.72 | MGMT (0.52) | MGMTCDK1CCNB1CCNA2CDK2 | |
| SCHEMBL31093748 | 0.72 | L3MBTL1 (0.48) | MGMTCDK1CCNB1CCNA2CDK2 | |
| SCHEMBL31394965 | 0.72 | SMN1; SMN2 (0.50) | MPOLTA4HMAPK14L3MBTL1MAOB | |
| SCHEMBL6244167 | 0.72 | LTA4H (0.61) | MGMTCDK1CCNB1CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11708376-B2 | Substituted imidazo[4,5-b]pyridines, imidazo[4,5-b]pyrazines, and oxazolo[4,5- b]pyrazines as mitochondrial uncouplers | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 2023-07-25 | — | — | US | disclosed |
| US-11708376-B2 | Substituted imidazo[4,5-b]pyridines, imidazo[4,5-b]pyrazines, and oxazolo[4,5- b]pyrazines as mitochondrial uncouplers | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 2023-07-25 | — | — | US | disclosed |
| US-11708376-B2 | Substituted imidazo[4,5-b]pyridines, imidazo[4,5-b]pyrazines, and oxazolo[4,5- b]pyrazines as mitochondrial uncouplers | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 2023-07-25 | — | — | US | disclosed |
| EP-3781567-B1 | IMIDAZOPYRIDINES USEFUL AS MITOCHONDRIAL UNCOUPLERS | VIRGINIA TECH INTELLECTUAL PROPERTIES INC (US) | 2022-08-24 | — | — | EP | disclosed |
| US-20210238181-A1 | IMIDAZOPYRIDINES USEFUL AS MITOCHONDRIAL UNCOUPLERS | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 2021-08-05 | — | — | US | disclosed |
| US-20210238181-A1 | IMIDAZOPYRIDINES USEFUL AS MITOCHONDRIAL UNCOUPLERS | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 2021-08-05 | — | — | US | disclosed |
| EP-3781567-A1 | IMIDAZOPYRIDINES USEFUL AS MITOCHONDRIAL UNCOUPLERS | Virginia Tech Intellectual Properties, Inc. (US) | 2021-02-24 | — | — | EP | disclosed |
| WO-2019204816-A1 | IMIDAZOPYRIDINES USEFUL AS MITOCHONDRIAL UNCOUPLERS | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 2019-10-24 | — | — | WO | disclosed |
| WO-2019204816-A1 | IMIDAZOPYRIDINES USEFUL AS MITOCHONDRIAL UNCOUPLERS | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 2019-10-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210238181-A1 | IMIDAZOPYRIDINES USEFUL AS MITOCHONDRIAL UNCOUPLERS | GLS2, NDUFAF1, NDUFAB1 | MGMT 3868/4885CDK1 2676/4885CCNB1 1137/4885 |
| US-11708376-B2 | Substituted imidazo[4,5-b]pyridines, imidazo[4,5-b]pyrazines, and oxazolo[4,5- b]pyrazines as mitochondrial uncouplers | NDUFAF1, NDUFAB1, GLS2 | MGMT 3572/4885CDK1 2347/4885CCNB1 1095/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.